Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1988-10-20
1990-08-28
Lovering, Richard D.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
4284022, 424450, 514 37, 514922, A61K 9127
Patent
active
049524054
ABSTRACT:
A method of selectively enhancing efficacy of gentamicin, when used in the treatment of Mycobacterium avium Complex (MAC), by intravenous administration of the drug in liposomal form. Gentamicin-liposomes are comparable to amikacinliposomes in activity against MAC infection in the bloodstream and substantially more effective against MAC infection residing in liver and spleen.
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Chem. Abstracts, vol. 106, No. 3, Abstract 15636s, Wallace et al., "Susceptibility of Slowly Growing Mycobacteria . . . ", 1986 in J. Clin. Microbiol. 24(6), 149-155.
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Chem. Abstracts, vol. 107, No. 25, Abstract 232920f, Bermudez et al., "Intracellular Killing of Nycobacterium Avium Complex . . . ", 1987 in J. Infect. Dis., 156(3), 510-513.
Chem. Abstracts, vol. 110, No. 22, Abstract 199086w, Saito et al., "Therapeutic Efficacy of Liposome-Entrapped . . . ", 1989 in Antimicrob. Agents Chemother, 33(4), 429-433.
Duzganes et al., "Enhanced Effect of Liposome Encapsulated Amikacin . . . ", 1988; Antimicrob. Agents Chemother, (32) 1404-1411.
Ginsberg, R., "Treatment of a Model of Gram-Negative Pneumonia with Liposome-Entrapped Gentamicin", 1987; Therapeutic Applications of Liposomes, Third Princeton-Liposome Conference Proceedings Highlights, pp. 7-9.
Pattisapu et al., "Comparative Activities of Free and Loposome Encapsulated Amikacin Against Mycobacterium Avium Complex (MAC)", 1988; J. Cel. Biochem. Supplement 12B:250.
Scheier et al., "Sustained Release of Liposome Encapsulated Gentamycin . . . ", 1987; J. Controlled Rel. (5) 187-192.
Covert John M.
Dehlinger Peter J.
Liposome Technology, Inc.
Lovering Richard D.
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