Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Monomer contains oxygen
Patent
1990-05-11
1992-02-18
Rollins, John W.
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Monomer contains oxygen
514824, 514724, A61K 31745
Patent
active
050892606
ABSTRACT:
In accordance with the present invention, a method is provided for treating tissue damaged by ischemia. More particularly, the present invention relates to a method for treating tissue damaged by ischemia comprising injecting certain ethylene oxide-propylene oxide condensation surface-active copolymers.
The surface-active copolymer can be an ethylene oxide-propylene oxide condensation product with the following general formula:
REFERENCES:
patent: Re29909 (1979-02-01), Kurtz
patent: 2674619 (1954-04-01), Lundsted
patent: 2854378 (1958-09-01), Buckwalter et al.
patent: 3089818 (1963-05-01), Stone
patent: 3140232 (1964-07-01), Noseworthy
patent: 3450502 (1980-06-01), Hymes
patent: 3577522 (1971-05-01), Hymes
patent: 3590125 (1971-06-01), Hymes
patent: 3641240 (1972-02-01), Hymes et al.
patent: 3740421 (1973-06-01), Schmolka
patent: 3867521 (1975-02-01), Miskel et al.
patent: 3956259 (1976-05-01), Garcia et al.
patent: 3980772 (1976-09-01), Ginger et al.
patent: 4073886 (1978-02-01), Kehm
patent: 4100271 (1978-07-01), Kreszanoski
patent: 4179337 (1979-12-01), Davis et al.
patent: 4186253 (1980-01-01), Yokoyama et al.
patent: 4305922 (1981-12-01), Rhodes
patent: 4395393 (1983-07-01), Schmolka
patent: 4407790 (1983-10-01), Oakes et al.
patent: 4600652 (1986-07-01), Solomon et al.
patent: 4609546 (1986-09-01), Hiratani
Schmolka, I., "A Review Of Block Polymer Surfactants", Journal of the American Oil Chemists Society, 54, No. 3, pp. 110-116 (1977).
Block and Graft Copolymerization, vol. 2, (ed. by R. J. Ceresa, John Wiley & Sons, 1976) "The Applications of Block Copolymer Polyol Surfactants", L. G. Lundsted and I. R. Schmolka; pp. 174 through 205 and pp. 255 through 272 (references).
Reindorf, C. A., "Perfluorocarbon Compounds: Effects on the Rheological Properties of Sickle Erythrocytes in vitro", American Journal of Hematology, vol. 19, pp. 229-236 (1985).
Vercellotti, G. M. "Activation of Plasma Complement by Perfluorocarbon Artificial Blood: Probable Mechanism of Adverse Pulmonary Reactions in Treated Patients and Rationale for Corticosteroid Prophylaxis", Blood, vol. 59, pp. 1299-1304 (1982).
Rodeheaver, G. T., "Pluronic F-68: A Promising New Skin Wound Cleanser", Ann Emerg Med, 9:11, pp. 572-576 (1980).
Padilla, F., et al., "Effect of Fluorocarbon emulsions on the mechanical fragility of normal and sickle cells: in vitro studies" Federation Proceedings, vol. 34, pp. 1510-1512 (1975).
Janoff, A. S., et al., "The Modification of Human Erythrocyte Membrane Structure by Membrane Stabilizers: An Electron Spin Resonance Study", American Journal of Hematology, vol. 10, pp. 171-179 (1981).
Moore, A. R., et al, "Reduction Of Splenic Vascular Resistance During Profusion By Pluronic F-68", Journal of Surgical Research, vol. 8, No. 12, pp. 563-566, (1968).
Benner, K. U. et al, "Cold-Induced Platelet Aggregation In Vivo And Its Inhibition By A Nonionic Surface Active Substance", Thrombosis Research, vol. 2, pp. 331-342, (1973).
Hymes, A. C., et al, "The Influence Of An Industrial Surfactant Pluronic F-68, In The Treatment of Hemorrhagic Shock", Journal of Surgical Research, vol. 11, pp. 191-197, (1971).
Hoie, J., et al, "Effects of Pluronic F68, Poloralkol, On Vascular Resistance In Vivo" Journal of Surgical Research, vol. 11, pp. 515-517, (1971).
Grover, F. L. et al, "A Nonionic Surfactant And Blood Viscosity", Arch. Surg., vol. 106, pp. 307-310, (1973).
Grover, F. L. et al, "The Effect of Pluronic F-68 On Circulatory Dynamics And Renal And Carotid Artery Flow During Hemorrhagic Shock", Journal of Surgican Research, vol. 17, pp. 30-35, (1974).
Ketchum, L. D. et al, "Pharmacological alterations in the clotting mechanism: Use in microvascular surgery", Journal of Hand Surgery, vol. 3, pp. 407-415, (1978).
Ketchum, Lynn D. et al, "Experimental Use of Pluronic.RTM. F-68 In Microvascular Surgery", Plastics and Reconstructive Surgery, vol. 53, pp. 288-292, (1974).
Vasko, K. A., et al., "Poloxalkol.RTM. (Pluronic F-68): A priming solution for cardiopulmonary bypass", Trans. Am. Soc. Artif. Int. Organs, 18, 526-531 (1972).
Block, N. L., et al., "Acutely traumatized canine ureter, Effects of low molecular weight dextran and surfactant Pluronic F-68", Urology, vol. III 190-194 (1974).
Knize, D. M., et al, "Use of antisludging agents in experimental cold injuries", Surgery, Gynecology & Obstetrics, vol. 129, pp. 1019-1026, (1969).
Gaehtgens, et al., "Disaggregation of Human Red Blood Cells by Various Surface-Active Agents as Related to Changes of Cell Shape and Hemolysis", Act Heamat. vol. 33, pp. 82-89 (1975).
Smillie, et al., "Cryopreservation of Human Platelets with Polyvinylpyrrolidone" Transfusion, vol. 21, pp. 552 through 556, (1981).
Organ Perfusion and Preservation, (ed. by Norman, J. C., Appleton-Century-Crofts, (1968)), Paton, B. C., et al. "The use of a nonionic detergent added to organ perfusates" pp. 105 through 120.
Advances in Blood Substitute Research (ed. by Bolin, et al., Alan R. Liss, Inc. New York, (1983)) Sugi, et al., The use of Fluosol-DA (FDA) in emergency situations: a report of 67 clinical cases, Abstract/451.
Technical bulletin entitled "Performance Chemicals".
Technical bulletin entitled "Pluronic.RTM. Block copolymer surfactants".
Perfluorochemical Blood Substitutes, Technical Information Ser. No. 5, Jun. 30, 1978, Revised, Jul. 1, 1981. Manufacturer: The Green Cross Corporation.
The Patent Cooperation Treaty International Search Report for PCT Patent Application No. PCT/US87/01067.
Patent Cooperation Treaty International Search Report for the PCT Patent Application No. PCT/US87/01747.
Lane, T. A., et al., "Reduction in the toxicity of a component of an artificial blood substitute by supercritical fluid fractionation", Transfusion, vol. 28, pp. 375-378, (1987).
Lane, T. A., et al., Paralysis of phagocyte migration due to an artificial blood substitute", Blood, vol. 64, pp. 400-405, (1984).
Spiess, B. D., et al., "Protection from cerebral air emboli with perfluorocarbons in rabbits", Stroke, vol. 17, pp. 1146-1149, (1986).
Kanter, K. R., et al., "Superiority of perfluorocarbon cardioplegia over blood or crystalloid cardioplegia", Circulation, vol. 64, pp. II-75-II-80, (1981).
Harjula, A., et al., "Perfluorocarbon solution as a myocardial preservative", J. Applied Cardiology, vol. 2, pp. 121-136, (1987).
Tokioka, M. D., et al., "Effects of intracoronary infusion of arterial blood or Fluosol-DA 20% or regional myocardial metabolism and function during brief coronary artery occlusions", Laboratory Investigation, vol. 75, pp. 473-481, (1987).
Benner, K. U., et al., "Uber die Wirkung von Pluronic.RTM. F68, einem polyoxypropylene-Polyoxyathylen-Kondensat, auf die ADP-induzierte Thrombocytenaggegation in vitro", Pfugers Arch., vol. 315, pp. 45-52 (1970).
Forman, M. B., et al., "Reduction of infarct size with intracoronary perfluorochemical in a canine preparation of reperfusion", Circulation, vol. 71, pp. 1060-1068, (1985).
Forman, M. B., et al., "Beneficial long-term effect of intracoronary perfluorochemical on infarct size and ventricular function in a canine reperfusion model", J. Am. Col. of Cardiol., pp. 1082-1090 (May, 1987).
Goodman, R. L., et al., "Perfluorocarbon emulsions in cancer therapy: preliminary observations on presently available formulations", Int. J. Radiation Oncology Biol. Phys., vol. 10, pp. 1421-1424, (1984).
Duncan Alexander
Hunter Robert L.
Emory University
Rollins John W.
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