Method of treating ischemia-related neuronal damage

Details Method of treating ischemia-related neuronal damage Method of treating ischemia-related neuronal damage

1989-11-22

1991-09-24

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 14, 530324, 530325, 530326, A61K 3702, C07K 708, C07K 710

Patent

active

050514032

ABSTRACT:
A method of reducing neuronal damage related to an ischemic condition in a human patient, such as stroke-induced damage, by administration of a binding/inhibitory omega-conotoxin peptide.

REFERENCES:
patent: 4447356 (1984-05-01), Olivera et al.
patent: 4925664 (1990-05-01), Jackson et al.
patent: 4950739 (1990-08-01), Cherksey et al.
Olivera et al., Science, vol. 230, (1985) pp. 1338-1343.
Gray et al., Ann. Rev. Biochem., 57 pp. 655-700 (1988).
Ahmad, S. et al., Brain Research, 453:247-256 (1988).
Anderson, A. J., et al., Neuroscience Letts., 82:177-180 (1987).
Bennett, J. P. et al., Neurotransmitter Receptor Binding, pp. 61-89, Raven Press, N.Y. (1983).
Chou, P. Y., Fasman, G. D. Biophysics J., 26, pp. 367-384 (1979).
Gray, W. R., et al., Ann. Rev. Biochem., 57, pp. 655-700 (1988).
Haley, T., et al., Brit. J. Pharmacol., 23, pp. 12-15 (1957).
Kessler, H., et al., Angew. Chim. Int. Eng. Ed., 27, pp. 490-536 (1988).
Kirino, T., Brain Research, 239, pp. 57-69 (1982).
McCleskey, E. W., et al. PNAS, 84, pp. 4327-4331 (1987).
Morel, N., Meunier, F-M., J. Neurochem., 36, pp. 1766-1773 (1981).
Olivera, B., et al., Science, 230, pp. 1338-1343 (1985).
Pulsinelli, W. A., et al., Stroke, 10, pp. 267-272 (1979).
Sano, K., et al., Eur. J. Pharmacol., 141, pp. 235-141 (1987).
Schweitzer, E., J. Neurosci., 7, pp. 2948-2956 (1987).
Tsien, R. W., et al., TINS, 11, pp. 431-438 (1988).
Van Reempts, J., et al., Acad. Anaesthesiolica Belge, 35, Suppl., pp. 209-218 (1984).
Wauquier, A. et al., Neuroscience and Biobehavioral Reviews, 11 pp. 287-306 (1987).
Yamaguchi, T., Klatzo, I., in Cerebral Ishemia, (Bes, A., Braquet, P., and Sisejo, B. K. eds.), Elsevier Sciences Publ., pp. 13-24 (1984).
Yamashiro, D., Int. J. Protein Peptide Res., 30, pp. 9-12 (1987).
Bean, B. P., Annu. Rev. Physiol. 51:367-84 (1989).
Choi, D. W., "Calcium-Mediated Neurotoxicity: Relationship to Specific Channel Types and Role in Ischemic Damage".
Greenberg, D. A., Curr. Neurol. 6:91-121 (1986).
Hossmann, K. -A, "Calcium Antagonists for the Treatment of Brain Ischemia: A Critical Appraisal".
Marqueze, Beatrice, et al., Molecular Pharmacology, 34:87-90.
Tateishi, A., et al., Stroke 20:1044-1050 (1989).
Vibulsreth, S., et al., "Failure of Nimodipine to Prevent Ischemic Neuronal Damage in Rats.".

Affiliated with

Also associated with

Rating

Method of treating ischemia-related neuronal damage does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of treating ischemia-related neuronal damage, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treating ischemia-related neuronal damage will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1696679