Method of treating inflammation

Details Method of treating inflammation Method of treating inflammation

1996-11-01

1998-10-20

Davenport, Avis M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 514 13, 514 14, 514 15, 530321, 530324, 530325, 530326, A61K 3800, A61K 3802, C07K 500, C07K 700

Patent

active

058246452

ABSTRACT:
A method of producing analgesia in nociceptive and neuropathic pain is disclosed. The method includes administering to a subject an omega conopeptide which is characterized by its ability to (a) inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind selectively to omega conopeptide MVIIA binding sites present in neuronal tissue. Also disclosed are novel omega conotoxin peptides effective in producing analgesia.

REFERENCES:
patent: 4975446 (1990-12-01), Trager et al.
patent: 5189020 (1993-02-01), Miljanich et al.
patent: 5587454 (1996-12-01), Justice et al.
Andersson, S.E. and Le Greves, P., "Ruthenium Red and Capsaicin Induce a Neurogenic Inflammatory Response in the Rabbit Eye: Effects of .omega.-conotoxin GVIA and tetrodotoxin," Eur. J. Pharmacol., 209:175-183 (1991).

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