Method of treating hyperlipidemic and hyperglycemic...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

Reexamination Certificate

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C514S167000, C514S170000, C514S171000, C514S172000

Reexamination Certificate

active

06875758

ABSTRACT:
The invention provides a method of using pregnadienones and pregnadienols represented by the structural formula (I) as shown herein belowWherein X═OH or O or combination thereof and positioning of olefinic bonds are at 4(5); 5(6); 16(17); 17(20) or various combinations and said compounds containing at least one olefinic bond in or on their D-ring for the treatment of hyperlipidemic and hyperglycemic conditions in mammals, said method comprising administering an effective amount of the said compounds to the recipient mammals.

REFERENCES:
patent: 0 562 849 (1993-09-01), None
Arya, V., “Gugulipid,”Drugs of the Future, 13(7):618-619 (1988).
Collins, D., “Sex hormone receptor binding, progestin selectivity, and the new oral contraceptives,”American Journal of Obstetrics and Gynecology, 170(5)2:1508-1513 (1994).
London, R., “The New Era in Oral Contraception: Pills Containing Gestodene, Norgestimate, and Desogestrel,”Obstetrical and Gynecological Survey, 47(11):777-782 (1992).
Townsley, “Further Studies on the Regulation of Human Placental Steroid 3-Sulfatase Activity,”Endocrinology, 93(1): 172-181 (1973).
Ahmed-Sorour et al., “Role of Ovarian Hormones in the Long-Term Control of Glucose Homeostasis,”Hormone Research, 13(6):396-403 (1980).
Ghaleb et al., “Interaction of Progesterone with Insulin and Tolbutamide in Normal and Alloxan Diabetic Rats,” Journal ofDrug Research Egypt, 5(2):13-21 (1973).
Sutter-Dub et al., “Progesterone and Insulin-Resistance in the Pregnant Rat,”Diabete & Metabolisme (Paris), 7(2):97-104 (1981).

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