Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1996-05-07
1998-07-28
Peselev, Elli
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
536 72, 536 74, A61K 3170
Patent
active
057863385
ABSTRACT:
This invention is directed to a novel method for treating human patients with hypercholesterolemia with a macrolide antibiotic. More specifically, this invention is directed to the oral administration of an erythromycin compound or an erythromycin derivative for treating hypercholesterolemia. Most specifically, this invention teaches the novel oral administration of clarithromycin, troleandomycin, erythromycin, or azithromycin for treating human patients with hypercholesterolemia.
REFERENCES:
patent: 4482540 (1984-11-01), Gordon et al.
Achord, J.L., Review of Alcoholic Hepatitis, and Its Treatment, The American Journal of Gastroenterology, 88(11):1822-1828 (1993).
Alpers, D.H., et al., Fatty Liver: Biochemical and Clinical Aspects, Diseases of the Liver, 4th Ed., 25:815-829, 1224-1229 (1975).
Bacon, B.R., et al. Nonalcoholic Steatohepatitis: An Expanded Clinical Entity, Gastroenterology, 107:1103-1109 (1994).
Cohen, et al., The SGOT/SGPT Ratio: An Indicator of Alcoholic Liver Disease, Dig. Dis. Sci., 24:835-838 (1979).
Fortmann, et al., Disorders of Lipid Metabolism, Scientific American, 9 Metabolism:1-24 (1993).
Furuchi, T., et al., Bafilomycin A.sub.1, a Specific Inhibitor of Vacuolar-type H.sup.+ -ATPase, Blocks Lysosomal Cholesterol Trafficking in Macrophages, The Journal of Biological Chemistry, 258:27345-27348 (1993).
Goldberg, et al., VA Cooperative Study on Alcoholic Hepatitis IV, American Journal of Gastroenterology, 81;1029-1034 (1986).
Gregory, P.G., Cirrhosis of the Liver in Scientific American Medicine for Gastroenterology, pp. 1-18 (1995).
Havel, R.J., et al., Management of Primary Hyperlipidemia, The New England Journal of Medicine, 332:1491-1498 (1995).
Holme, I., et al., Risk factors and raised atherosclerotic lesions in coronary and cerebral arteries. Statistical analysis for the Oslo Study, Arteriosclerosis 1:250-256 (1981).
Isselbacher, K.J. et al., Infiltrative and Metabolic Disease affecting the Liver in Harrison's Principles of Internal Medicine, eds. Brawnwald, E. et al., pp. 1353--54 (1988).
Kannel, W.B., et al., Epidemiology of coronary atherosclerosis: Postmortem vs clinical risk factor correlation's. The Framingham Study. In: Gotto, A.M., Jr., et al., eds. International Symposium on Atheroscierosis, 5th, Houston, 1079; Atherosclerosis V. New York Springer-Verlag, pp. 54-56 (1980).
Kawashima, et al., New Cholesterol Biosynthesis Inhibitors MC-031 (O-Demethylchlorothericin), -032 O-Demethyhydroxychlorothricin), -033 and -034, Journal of Antibotics, 45(2):207-212 (1992).
Lipids Research Clinics Program, The Lipid Research Clinics Coronary Primary Prevention trial Results. I. Reduction in incidence of coronary heart disease, JAMA 251:351-364 (1984).
Ludwig, et al., Nonalcoholic Steatohepatitis. Mayo Clinic Experiences With A Hitherto Unnamed Disease, Mayo Clinic Proceedings, 55:434-438 (1980).
McGills, H.C., et al., Relationship of Lipoprotein cholesterol concentrations to experimental atherosclerosis in baboons, Artheriosclerosis 1:3-12 (1981).
Metropolitan Height and Weight Tables, New York: Metropolitan Life Insurance Company (1983).
Physicians' Desk Reference.RTM., pp. 405-407, 1789-1791 (1994).
Physicians' Desk Reference.RTM., pp. 421-423, 449, 651, 935, 937, 1841, 2102, and 2419 (1995).
Rudel, L.L., Plasma Liproproteins in Atherogenesis in Nonhuman Primates, Kalter, S.S. (ed.), University of Texas Press, Austin, Texas, pp. 37-57 (1980).
Gregory, P.G.; "Cirrhosis of the Liver"; Mar. 1995; Scientific American Medicine for Gastroenterology.
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