Method of treating hypercholesterolemia with a macrolide antibio

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

536 72, 536 74, A61K 3170

Patent

active

057863385

ABSTRACT:
This invention is directed to a novel method for treating human patients with hypercholesterolemia with a macrolide antibiotic. More specifically, this invention is directed to the oral administration of an erythromycin compound or an erythromycin derivative for treating hypercholesterolemia. Most specifically, this invention teaches the novel oral administration of clarithromycin, troleandomycin, erythromycin, or azithromycin for treating human patients with hypercholesterolemia.

REFERENCES:
patent: 4482540 (1984-11-01), Gordon et al.
Achord, J.L., Review of Alcoholic Hepatitis, and Its Treatment, The American Journal of Gastroenterology, 88(11):1822-1828 (1993).
Alpers, D.H., et al., Fatty Liver: Biochemical and Clinical Aspects, Diseases of the Liver, 4th Ed., 25:815-829, 1224-1229 (1975).
Bacon, B.R., et al. Nonalcoholic Steatohepatitis: An Expanded Clinical Entity, Gastroenterology, 107:1103-1109 (1994).
Cohen, et al., The SGOT/SGPT Ratio: An Indicator of Alcoholic Liver Disease, Dig. Dis. Sci., 24:835-838 (1979).
Fortmann, et al., Disorders of Lipid Metabolism, Scientific American, 9 Metabolism:1-24 (1993).
Furuchi, T., et al., Bafilomycin A.sub.1, a Specific Inhibitor of Vacuolar-type H.sup.+ -ATPase, Blocks Lysosomal Cholesterol Trafficking in Macrophages, The Journal of Biological Chemistry, 258:27345-27348 (1993).
Goldberg, et al., VA Cooperative Study on Alcoholic Hepatitis IV, American Journal of Gastroenterology, 81;1029-1034 (1986).
Gregory, P.G., Cirrhosis of the Liver in Scientific American Medicine for Gastroenterology, pp. 1-18 (1995).
Havel, R.J., et al., Management of Primary Hyperlipidemia, The New England Journal of Medicine, 332:1491-1498 (1995).
Holme, I., et al., Risk factors and raised atherosclerotic lesions in coronary and cerebral arteries. Statistical analysis for the Oslo Study, Arteriosclerosis 1:250-256 (1981).
Isselbacher, K.J. et al., Infiltrative and Metabolic Disease affecting the Liver in Harrison's Principles of Internal Medicine, eds. Brawnwald, E. et al., pp. 1353--54 (1988).
Kannel, W.B., et al., Epidemiology of coronary atherosclerosis: Postmortem vs clinical risk factor correlation's. The Framingham Study. In: Gotto, A.M., Jr., et al., eds. International Symposium on Atheroscierosis, 5th, Houston, 1079; Atherosclerosis V. New York Springer-Verlag, pp. 54-56 (1980).
Kawashima, et al., New Cholesterol Biosynthesis Inhibitors MC-031 (O-Demethylchlorothericin), -032 O-Demethyhydroxychlorothricin), -033 and -034, Journal of Antibotics, 45(2):207-212 (1992).
Lipids Research Clinics Program, The Lipid Research Clinics Coronary Primary Prevention trial Results. I. Reduction in incidence of coronary heart disease, JAMA 251:351-364 (1984).
Ludwig, et al., Nonalcoholic Steatohepatitis. Mayo Clinic Experiences With A Hitherto Unnamed Disease, Mayo Clinic Proceedings, 55:434-438 (1980).
McGills, H.C., et al., Relationship of Lipoprotein cholesterol concentrations to experimental atherosclerosis in baboons, Artheriosclerosis 1:3-12 (1981).
Metropolitan Height and Weight Tables, New York: Metropolitan Life Insurance Company (1983).
Physicians' Desk Reference.RTM., pp. 405-407, 1789-1791 (1994).
Physicians' Desk Reference.RTM., pp. 421-423, 449, 651, 935, 937, 1841, 2102, and 2419 (1995).
Rudel, L.L., Plasma Liproproteins in Atherogenesis in Nonhuman Primates, Kalter, S.S. (ed.), University of Texas Press, Austin, Texas, pp. 37-57 (1980).
Gregory, P.G.; "Cirrhosis of the Liver"; Mar. 1995; Scientific American Medicine for Gastroenterology.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method of treating hypercholesterolemia with a macrolide antibio does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of treating hypercholesterolemia with a macrolide antibio, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treating hypercholesterolemia with a macrolide antibio will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-23679

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.