Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1990-06-07
1992-07-14
Berch, Mark L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
A61K 31555, C07F 1500
Patent
active
051303086
ABSTRACT:
A compound of the general formula: ##STR1## wherein R.sub.1 is hydrogen, a hydroxy group or a C.sub.2 -C.sub.6 alkanoyloxy group, R.sub.2 is hydrogen or a hologen atom, R.sub.3 is hydrogen or a C.sub.1 -C.sub.6 alkyl group, R.sub.4 is a hydroxy group or a C.sub.2 -C.sub.6 alkanoyloxy group, R.sub.5 is hydrogen or a hologen atom and R.sub.6 is hydrogen or a halogen atom, Alk is a C.sub.2 -C.sub.10 alkylene chain where 4 neighboring CH.sub.2 groups may also be replaced by a 1,4-phenylene ring, A-B is the group HN--CH.sub.2 --CH.sub.2 --NH.sub.2, H.sub.2 N--CH.sub.2 --CH--CH.sub.2 --NH.sub.2 or ##STR2## and R.sub.7 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group or a phenyl radical and X stands for the equivalent of a physiologically acceptable anion. The compound is useful for the treatment of hormone dependent tumors.
REFERENCES:
T. A. Connors et al Platinum Coordination Complexes in Cancer Chemotherapy, Berlin, 1974, pp. 132-136.
Sandra J. Meischen et al, Journ. Nat. Cancer Inst. 57, (1976) pp. 841-845.
Sarma et al., Chem-Biol Interactions, 46 (1983) pp. 219-232.
Synthesis and Spectroscopic Studies of Potential Anticancer [Platinum(II)(2,2'-Bipyridine)(Amino Acid)].sup.n+ (n=1 or 2) Complexes; Kumar, et al; Journal of Inorganic Biochemistry 23, 1-11 (1985).
Bowler, J.A.C.S. 106, 6102 (1984).
Haggins, Cancer Res. 25(1965) 1163-7.
Cancer Treatment Review 3, 205(1976).
Engel Jurgen
Knebel Norbert
Schonenberger Helmut
von Angerer Erwin
Asta Pharma
Berch Mark L.
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