Method of treating HIV infections with 2',3'-dideoxy-3'-fluoro-5

Details Method of treating HIV infections with 2',3'-dideoxy-3'-fluoro-5 Method of treating HIV infections with 2',3'-dideoxy-3'-fluoro-5

1993-05-17

1996-11-12

Kunz, Gary L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2855, A61K 3170, C07H 19073

Patent

active

055741495

ABSTRACT:
A method for treating HIV infections comprising administering a composition whose active ingredient is 2',3'-dideoxy-3'-fluoro-5'-chlorouridine.

REFERENCES:
patent: 3328388 (1967-06-01), Shen et al.
patent: 5153180 (1992-10-01), Mattes et al.
Matthes et al., "3'-Fluoro-substituted Deoxynucleosides As Potential Anti-AIDS Drugs", paper presented at symposium on AIDS, Berlin, Sep. 7-10, 1988.
Jan Balzarini, et al.; 5-Halogeno-3'-fluoro-2', 3'-dideoxyuridines as Inhibitors of Human Immunodeficiency Virus (HIV); Potent and Selective Anti-HIV Acitivity of 3'-Fluoro-2',3'-dideoxy-5-chlorouridine; 1989; pp. 571-577.
Susan Daluge et al.; 5-Chloro-2',3-Dideoxy-3'Fluorouridine (935U83), a Selective Anti-Human Immunodeficiency Virus Agent with and Improved Metabolic and Toxicological Profile; Vo. 38; No. 7; May 9, 1994; pp. 1590-1603.

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