Method of treating HIV infection and related secondary infection

Details Method of treating HIV infection and related secondary infection Method of treating HIV infection and related secondary infection

1994-01-24

1997-04-29

Crouch, Deborah

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514924, 514934, A61K 4800

Patent

active

056249128

ABSTRACT:
Oligonucleotides, polynucleotides and derivatives thereof, such as defibrotide, are agents of genetic modulation at the levels of transcription, translation, secondary messengers and cellular signal transduction systems. Such agents can be used to treat HIV infection. Preferably, treatment involves modifying the dose of such agents in response to observed fluctuations (e.g., increase, decrease, appearance, disappearance) in normal, disease and repair markers.

REFERENCES:
patent: 4649134 (1987-03-01), Bonomini
patent: 4693995 (1987-09-01), Prino et al.
patent: 4795744 (1989-01-01), Carter
Sullenger et al (1990) Cell 63, 601-608.
Ferrero et al., Chemical Abstract No. 109(13):104533m, 1988.
Marni et al., Chemical Abstract No. 114(7):55511v, 1990.
Bilsel et al., 1990, Interaction of .sup.3 H-defibrotide with cultured human umbilical vein endothelial cells, Thrombosis Research, 58(5):455-460.
Cook et al., Chemical Abstract No. 99:52230p, 1983.
Girard et al., Chemical Abstract No. 96:168754e, 1982.
Gendelman et al., Chemical Abstract No. 113:170225w, 1990.
Merck Index 11th Ed., 1990, p. 192 (#1244--Biotin) and 449 #2851--Defibrotide).
Bonomini et al., 1986, Haemostatsis, 16 (suppl. 1):48-50.
Sabba et al., 1988, Internat'l J. Clin. Pharma., Therapy and Toxicol., 26(5):249-252.

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