Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1985-01-15
1989-07-25
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514255, 514356, 514428, 514523, 514815, A61K 3155, A61K 31495, A61K 3144, A61K 3140
Patent
active
048514047
ABSTRACT:
A therapeutic method of treatment of hemoglobinopathy by administration of a drug capable of blocking the Ca.sup.+2 channel in and out of muscle cells. Drugs known to possess this capability are 1,4-dihydropyridines, .beta.-phenethylamines, benzothiazepines, ethylenediamines and diaryl alkyl amines. These drugs are known to block the influx of Ca.sup.+2 into the cardiac muscle and are known to be useful in treatment of such heart muscle conditions as angina. It has now been unexpectedly discovered that such drugs can be used to treat hemoglobinopathy.
REFERENCES:
patent: 4383997 (1983-05-01), Boucher
"Calcium Blockers", edited by Flaim et al., Urban & Schwarzenberg, Baltimore-Munich 1982, pp. 139, 140, 170-173, 183-187 & 196.
Ann. Soc. Med. Trop. 1969, 49 z, 205-210.
J. Int. Med. Res. (1976) 4, 375-381.
"Development of Therapeutic Agent for Sickle Cell Disease", 1979, North-Holland Pub. Co. AM.-N.Y-OX. pp. 7-11 & 195-202.
Boguslaski M. G.
Gray E. P.
Miles Inc.
Waddell Frederick E.
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