Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-01-07
1985-11-12
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3147
Patent
active
045528845
ABSTRACT:
A method for the treatment of heart failure in a mammal comprises the administration to the mammal of a quinolone of the general formula I, ##STR1## wherein m is 0 or 1; n is 0, 1 or 2; and R is hydrogen, halo, methyl or trifluoromethyl. A preferred method of the invention comprises the treatment of chronic heart failure in a mammal by the oral administration of a quinolone of formula I. Preferred compounds of formula I are 7-fluoro-1-methyl-3-methylsulphinyl-4-quinolone and 1-methyl-3-methylsulphonylmethyl-4-quinolone.
REFERENCES:
patent: 4302460 (1981-11-01), Davies et al.
patent: 4442109 (1984-04-01), Davies
patent: 4447435 (1984-05-01), Davies
Sim Malcolm F.
Yates David B.
Hueschen Gordon W.
Robinson Douglas W.
The Boots Company PLC
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