Method of Treating Glaucoma Using Oxadiazolyl or Thiadiazolyl Te

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514340, A61K 3144, C07D41904

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active

055591388

ABSTRACT:
This invention relates to the treatment of glaucoma by topically administering a compound selected among ##STR1## wherein Z, R, and R.sup.1 are defined in the specification, and a pharmaceutically acceptable salt thereof.

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Tune et al. "Anticolinergic delirium caused by topical homatropine ophthalmologic solution" Index Medicus 330504 (1992).
Sugrue "The pharmacology of antiglaucoma drugs" Pharm. Ther. v. 43, pp. 91-138 (1989).
Bodor et al. "Improved delivery through biological membrane" J. Med. Chem. v. 31, pp. 100-106 (1988).
Wilbraham et al. "Organic and biological chemistry" The Benjamin/Cummins Pub. pp. 266-269 (1985).

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