Method of treating fibrotic disorders

Details Method of treating fibrotic disorders Method of treating fibrotic disorders

1992-04-20

1994-05-17

Patterson, Jr., Charles L.

Drug, bio-affecting and body treating compositions

Lymphokine

Interferon

424 854, 424 856, 435 695, 435 6951, 530350, 530351, 536 221, 536 232, A61K 3766, C12P 2106, C07K 300, C07H 1512

Patent

active

053126211

ABSTRACT:
A novel method of treating fibrotic disorders in humans comprises the administration of a sufficient quantity of a composition containing a human alpha- or beta-interferon to raise the total concentration of such interferon in the affected tissue area to about 10 to about 4.times.10.sup.7 IU per cubic centimeter. The interferons used can be naturally derived or recombinant DNA-derived. The interferon composition can be administered by any indicated conventional method and can include any pharmaceutically acceptable, interferon-compatible vehicle.

REFERENCES:
Jimenez et al. "Selective Inhibition of Human Diploid . . . " J. Clin. Invest. 74:1112-1116 (1984).
Duncan et al. ".gamma. Interferon is the Lymphokine . . . " J. Exp. Med. 162:516-527 (1985).
Wickramasinghe et al. ".gamma.-Interferon in Primary . . . " Lancet 2:1524-1525 (1987).

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