Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Food or edible as carrier for pharmaceutical
Patent
1993-02-01
1994-12-13
Michl, Paul R.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Food or edible as carrier for pharmaceutical
514276, 514450, A23K 1165
Patent
active
053728181
ABSTRACT:
A novel method for using domperidone, a dopamine receptor antagonist, for treating fescue toxicosis in animals is provided. Fescue toxicosis is caused by animals grazing on endophyte-infected fescue grass. Treatment of the animal with various dosages of domperidone results in effective management of the toxin. The domperidone treatments do not cause any substantial adverse behavioral or neurological side effects in the animal. Domperidone is a more effective treatment for fescue toxicosis than previously-known agents such a metoclopramide and sulpiride.
REFERENCES:
patent: 4066772 (1978-01-01), Vandenberk et al.
patent: 4755519 (1988-07-01), Dougherty et al.
patent: 4847243 (1989-07-01), Wallace
patent: 4880632 (1989-11-01), Lipham et al.
Drug Facts and Comparisons, 1991 Edition, A Division of J. B. Lippincott Company pertinent p. 2561.
Effects of Domperidone and Thyrotropin-Releasing Hormone on Secretion of Luteinizing Hormone and Prolactin During the Luteal Phase and Following Induction of Luteal Regression in Sheep, D. R. Deaver et al., Domestic Animal Endocrinology, vo. 4(2):95-102, 1987.
"Notice of Drug Shipment" forms relative to domperidone for fescue toxicosis in horses, Dee L. Cross, Division of Agriculture and Natural Resources, Clemson University, Jun. 8, 1993.
Domperidone, A Specific In Vitro Dopamine Antagonist, Devoid of In Vivo Central Depaminergic Activity, Pierre M. Laduron et al., Biochemical Pharmacology vol. 28, pp. 2161-2165, Janssen Pharmaceutica, B-2340 Beerse, Belgium.
Minireview, The Substituted Benzamides--A novel Class of Dopamine Antagonists, P. Jenner et al., Life Sciences, vol. 25, pp. 479-486, Institute of Psychiatry & King's College Hospital Medical School, Denmark Hill, London SE5, UK.
Cross Dee L.
Strickland James R.
Benston, Jr. William E.
Clemson University
Michl Paul R.
LandOfFree
Method of treating fescue toxicosis with domperidone does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of treating fescue toxicosis with domperidone, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treating fescue toxicosis with domperidone will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1191843