Method of treating eye disorders with silicon/fluorosilicone cop

Drug – bio-affecting and body treating compositions – Topical body preparation containing solid synthetic organic... – Ophthalmic preparation

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514 63, 514912, A61K 3174, A61K 31695

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active

053364872

ABSTRACT:
A method of treating an intraocular structural disorder of an eye comprising introducing into the intraocular structure under treatment a liquid silicone/fluorosilicone oil in an amount effective to treat the intraocular structural disorder.

REFERENCES:
patent: 4490351 (1984-12-01), Clark, Jr.
Silicone Oil in the Treatment of Complicated Retinal Detachments, K. Lucke and H. Laqua, Springer-Verlag, N.Y., 1990, pp. 8-15, 124, 125.
"Experimental Studies of the Combined Use of Vitreous Substitutes of High and Low Specific Gravity", Sparrow et al., Retina, 12:134-140, (1992).
"Long-Term Vitreous Replacement in Primates with Intravitreal Vitreon or Vitreon Plus Silicone", Peyman et al., Ophthalmic Surgery, V. 122, No. 11, pp. 657-664 (Nov. 1991).
"Vitreous Injections: When to do Them and Why", Tolentino et al., Ophthalmology Annual, 1989, Raven Press, N.Y., pp. 337-349.
"Ciliary Sulcus Fixation of a Dislocated Posterior Chamber Intraocular Lens Using Liquid Perfluorophenanthrene", Fanous et al., Ophthalmic Surgery, V. 23, No. 8, pp. 551-552 (Aug. 1992).
"Perfluorocarbon Liquids in the Management of Traumatic Retinal Detachments", Chang et al., Opthalmology, vol. 96, No. 6, pp. 785-792 (Jun. 1989).
"Low Viscosity Liquid Fluorochemicals in Vitreous Surgery", Chang, American Journal of Ophthalmology, 103:38-43, (Jan. 1987).
Proliferative Vitreoretinopathy, H. Freeman and F. Tolentino, Eds., Springer-Verlag, N.Y., 1988, pp. 162-165.
"Factors Contributing to the Emulsification of Intraocular Silicone and Fluorosilicone Oils", Nakamura et al., Investigative Ophthalmology and Visual Science V. 31, No. 4, pp. 647-656 (Apr. 1990).
"Analysis and Fractionation of Silicone and Fluorosilicone Oils for Intraocular Use", Nakamura et al., Investigative Ophthalmology and Visual Science, V. 31, No. 10, pp. 2059-2069 (Oct. 1990).
"Fluorinated Oils as Experimental Vitreous Substitutes", Miyamoto et al., Archives of Ophthalmology, vol. 104, p. 1053-1056 (Jul. 1986).
"Perfluorooctane in the Treatment of Giant Retinal Tears with Proliferative Vitreoretinopathy", Glaser et al., Ophthalmology, vol. 98, No. 11, pp. 1613-1621 (Nov. 1991).
"Management of the Dislocated Crystalline Lens with a Perfluorocarbon Liquid", Shapiro et al., American Journal of Ophthalmology, 112:401-405 (Oct. 1991).
"Ocular Toxicity of Low Molecular-Weight Components of Silicone and Fluorosilicone Oils", Nakamura et al., Investigative Ophthalmology and Visual Science vol. 32, No. 12, pp. 3007-3020 (Nov. 1991).
Brochure entitled "Vitreon", Vitrophage, Inc., Lyons, Ill. (1984).

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