Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Reexamination Certificate
2006-02-28
2006-02-28
Cook, Rebecca (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
Reexamination Certificate
active
07005429
ABSTRACT:
This invention provides a method of treating estrogen receptor positive carcinoma in a mammal in need thereof which comprises administering an antineoplastic amount of 17(α-dihydroequilin or a mammalian metabolic conjugate thereof orally, parenterally, transdermally, topically, rectally, intravaginally, intranasally, or intrabronchially. As such, the compounds of this invention are useful in treating estrogen receptor positive carcinomas such as carcinomas of the breast, uterus, ovary, fallopian tube, cervix, vagina, liver, pituitary, central nervous system, hypothalamus, bone, skin, kidney, urethra, prostate, and the like.
REFERENCES:
PDR, 43ed,(1989), pp. 2355-2358.
Escher et al., Current Views on the Management of Metastatic Mammary Carcinoma,:M. Clin., North America45:613-625 (1961).
Segaloff and Ochsner, “Results of Studies of the Cooperative Breast Cancer Group-1961-631.2,”Cancer Cehmotherapy Reports, 41:1-24 (1964).
Segaloff and Ochsner, “Progress Report: Results of Studies of the Cooperative Breast Cancer Group-1956-601.2,” Cancer Chemotherapy Reports, 11:109-141 (1961).
“Current Status of Hormone Therapy of Advanced Mammary Cancer,”Journal of American Medical Assoc. 146(5):471-477 (Jun. 1951).
Lewison et al., “Tracer Studies of Radioactive Sodium Estrone Sulfate (S35) in Cases of Advanced Breast Cancer,”Cancer. 537-548 (May 1951).
McCormick, “Benign and Malignant Diseases of the Breast,”Journal of American Medical Association146(5):461-464 (Jun. 1951).
Taylor et al., “Hormones in Breast Metastasis Therapy,”M. Clin. North American, 35:51-61 (1951).
Griboff, “The Rational and Clinical Use of Steroid Hormones in Cancer,”A.M.A. Archives of Internal Medicine89:635-685 (Apr. 1952).
Woodward, et al., “Changes in the Blood Chemistry of Patients with Disseminated Carcinoma of the Breast During Endocrine Therapy,”Cancer74(4):744-757 (Jul. 1954).
“Questions and Answers,” GP 7(1):82-84 (Jan. 1954).
Taylor, “Hormonal Modification in the Treatment of Disseminated Cancer of the Breast,”American Journal of Medicine21:688-696 (Nov. 1956).
Kennedy et al., “Surgery as an Adjunct to Hormone Therapy of Breast Cancer,”Cancer10(5):1055-1075 (Sep.-Oct. 1957).
Mustacchi et al., Frequency of Cancer in Estrogen-Treated Osteoporotic Women, in Segaloff, A.:Breat Cancer, the Second Biennial Louisiana Cancer Conference, New Orleans, Jan. 22-23, 1958, St. Louis, The C.V. Mosby Company, pp 163-169. (1958).
Block, “Endocrine Treatment of Advanced Mammary Cancer,”GP20(4), 85-96 (Oct. 1959).
Lemon, “Prednisone Therapy of Advanced Mammary Cancer,”Cancer12(1) 93-107 (Jan.-Feb. 1959).
Baker et al., “Hormonal Treatment of Metastatic Carcinoma of the Breast,”American Journal of Surgery99:538-543 (Apr. 1960).
Council on Drugs: “Androgens and Estrogens in the Treatment of Disseminated Mammary Carcinoma,”Journal of American Medical Association, 172 (12):1271-1283 (1960).
Kelley, “Medical Aspects of the Hormonal Treatment of Cancer,” Modern Medicine 28:117-126 (Apr. 1960).
Whitney, “The Endocrine Palliation of the Breast Cancer Patient,”The Journal of the Maine Medical Association, 51:433-438 (Dec. 1960).
Kennedy, “Massive Estrogen Administration in Premonopausal Women with Advanced Breast Cancer,”Cancer Chemotherapy Reports, 16:283-284 (Feb. 1962).
Kennedy, “Massive Estrogen Administration in Premonopausal Women with Advanced Breast Cancer,”Cancer15(3): 641-648 (May-Jun. 1962).
Wilson, “The Roles of Estrogen and Progesterone in Breast and Genital Cancer,”Journal of American Medical Association, 182 (4):327-331 (Oct. 1962).
Hertz et al., Administration of Massive Dosage of Estrogen to Breast and Prostatic Cancer Patients; Blood Levels Attained,:Ciba Foundation Colloquia, Endocrinology, 1:157:169 (1952).
Rukes and Galante, “Palliative Treatment of Metastatic Cancer of the Breast,”GP, 10(4), 83-93 (Oct. 1954).
Adair et al., “The Use of Estrogens and Androgens in Advanced Mammary Cancer,”The Journal of American Medical Association, 140(15), 1193-1200 (Aug. 1949).
Garland et al., “Roentgen and Steroid Hormone Therapy in Mammary Cancer Metastatic to Bone,”Journal of American Medical Association, 144(2):997-1004 (Nov. 1950).
Kennedy and Nathanson, “Effects on Intensive Sex Steroid Hormone Therapy in Advanced Breast Cancer,”Journal of American Medical Association, 152(12):1135-1141 (Jul. 1953).
Segaloff et al., “Hormonal Therapy in Cancer of the Breast,”Cancer, 7(4):758-763 (Jul. 1954).
Kennedy et al., “Massive Estrogen Administration in Premonopausal Women with Advanced Breast Cancer,”Abstract of Proceedings of American Association of Cancer Research3:239 (#146) (1961).
Kaufman and Goodwin, “Cancer of the Prostate: Diagnosis and Treatment,”The Journal of American Geriatrics Society, 4:296-305 (Mar. 1956).
Beck, “Hormonal Therapy of Carcinoma of the Breast,”Canadian Services Medical Journal, 13:607-613 (Oct. 1957).
Stearns and Gordon, “Changes in Microscopic Pathology of Prostatic Carcinoma Following Estrogen Therapy and Surgery,”The Journal of Urology, 79(2):333-338 (Feb. 1958).
Treves, The Treatment of Cancer, Espcecially Inoperalbe Cancer, of the Male Breast by Ablative Surgery (Orchiectomy, Adrenalectomy, and Hypophysectomy) and Hormone Therapy (Estrogens and Corticosteroids),Cancer, 12(4):820-832 (Jul.-Aug. 1959).
Reicher and Phillips, “Carcinoma of the Endometrium,”American Journal of Obstetrics and Gynecology, 82(2):417-423 (Aug. 1961).
Urban, Current Trends in Breast Cancer Treatment, Part III,New York State Journal of Medicine, 61:3469-3477 (Oct. 1961).
Fergusson, “some Aspects of the Conservative Management of Prostatic Cancer,”Proceedings of the Royal Society of Medicine, 56:81-88 (Feb. 1963).
Dederick et al., “Effect of Therapy upon Vaginal Smears in Breast Cancer patients,”Surgery, Gynecology&Obstetrics, 118(5): 1019-1023 (May 1964).
Green et al., “Treatment of Advanced Carcinoma of the Breast,”The American Journal of Surgery, 108:107-121(1964).
Rhoades, Progress in Management of Breast Cancer and Hypoestrogenism in the Aging Female,American Geriatrics Society, 12(9):877-880 (Sep. 1964).
Brendler and Prout, Jr., “A Cooperative Group Study of Prostatic Cancer: Stilbestrol Versus Placebo in Advanced Progressive Disease,”Cancer Chemotherapy Reports, 16:323-328 (Feb. 1962).
The Veterans Administrative Co-Operative Urological Research Group, “Treatment and Survival of Patients with Cancer of the Prostate,”Surgery, Gynecology&Obstetrics, 124(5): 1011-1017 (May 1967).
Whitmore, “Hormone Therapy in Prostatic Cancer,”The American Journal of Medicine, 21:697-713 (Jul.-Dec. 1956).
Dorfman. Cahpters 4 & 5 in “Methods in Hormone Research—Steroidal Activity in Experimental Animals and Man,”Academic Press, vol. 5, part C, New York (1966).
Holleb et al., “Cancer of Male Breast,”New York State Journal of Medicine, 544-553 (Feb. 1968).
Kaufman et al., “Rebound Regression in Advanced Mammary Carcinoma,”Surgery, Gynecology&Obstetrics, 113(5):635-640 (Nov. 1961).
Pfizer Spectrum: Mammary Cancer—Manipulations of the Milieu Interieur,Journal of American Medical Associaton, 153(8adv):21-23 (Oct. 1953).
Hall, “The Treatment of Inoperable Breast Cancer,”Medical Science, pp 497-510 (Apr. 25, 1961).
Physicians' Desk Reference, 1989, pp. 2355-2358.
Pharmac. Ther. 25:127 (1984) J.A. Furr and V.C. Jordan.
Transcript of Ad Hoc Subcommittee of the Fertility & Maternal Health Drugs Adv. Committee, Conjugated Estrogens:Bioequivalence Issuesp. 77-79 (publ. May 16, 1990).
Bex Frederick J.
Corbin Alan
Dey Michael S.
Cook Rebecca
Finnegan Henderson Farabow Garrett & Dunner L.L.P.
Wyeth
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