Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1990-07-23
1992-03-17
Doll, John
Drug, bio-affecting and body treating compositions
Lymphokine
5303873, 53038823, 530866, A61K 3900, C07K 1528
Patent
active
050967045
ABSTRACT:
A method of preventing eosinophilia associated with certain immune disorders is provided. The method comprises administering an effective amount of an antagonist to human interleukin-5. Preferably, the antagonist is a blocking monoclonal antibody specific for human interleukin-5, or a fragment or binding composition derived therefrom.
REFERENCES:
patent: 4355023 (1982-10-01), Ehrlich et al.
patent: 4642334 (1987-02-01), Moore et al.
Skerra et al, Science, vol. 240, pp. 1038-1041 (1988).
Hochman et al, Biochemistry, vol. 12, pp. 1130-1135 (1973).
Exley et al, Lancet, vol. 335, pp. 1275-1277 (1990).
Anasette et al., Transplantation, vol. 50, pp. 49-54 (1990).
Clarkson et al, New England J. Med., vol. 314, pp. 1236-1239 (1986).
Goldstein et al, New England J. Med., vol. 313, pp. 337-342 (1985).
Lowder et al, Cancer Surveys, vol. 4, pp. 359-375 (1985).
Frodin et al, Cancer Research, vol. 50, pp. 4866-4871 (1990).
Lopez, J. Exp. Med. (1/1988) 167: 219-224.
Schumacher, J. Immunology (9/1988) 141: 1576-81.
Sanderson et al., "Molecular and Cellular Biology of Eosinophil Differentiation Factor (Interleukin-5) and Its Effects on Human and Mouse B. Cells", Imm. Rev. 102: 29-50, 1988.
Warren et al., "Production of a T-cell Hybrid Producing a Lymphokine Stimulating Eosinophil Differentiation", Immunology 54: 615-623, 1985.
Warren et al., "Synergism Among Interleukin 1, Interleukin 3, and Interleukin 5 in the Production of Eosinophils from Primitive Hemopoietic Stem Cells", J. Immunol. 140: 94-99, Jan. 1, 1988.
Coffman Robert L.
Rennick Donna M.
Budens Robert D.
Doll John
Macevicz Stephen C.
Schering Corporation
LandOfFree
Method of treating eosinophilia does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of treating eosinophilia, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treating eosinophilia will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1474597