Method of treating endotoxin effects with 2-methylthio-ATP and a

Details Method of treating endotoxin effects with 2-methylthio-ATP and a Method of treating endotoxin effects with 2-methylthio-ATP and a

1993-10-15

1996-02-20

Kunz, Gary L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514921, A61K 3170, C07H 19167

Patent

active

054928982

ABSTRACT:
A method of treating mammals to reduce the deleterious effects of endotoxin and endotoxic shock mediators comprising administering a therapeutic amount of a 2-alkylthio-adenosine-5'-nucleotide. The preferred compound is 2-methylthio-adenosine-5'-triphosphate. The nucleotide used in this treatment inhibits lipopolysaccharide-induced GTPase activity.

REFERENCES:
patent: 3678162 (1972-07-01), Maguire et al.
patent: 4826823 (1989-05-01), Cook et al.
Lehninger, Albert L. "Biochemistry: The Molecular Basis for Cell Structure and Function", Second Edition. Worth Publishers, Inc. 1975, p. 218.
Gough et al. J. Med. Chem. 16(10):1188-1190, 1973.

Affiliated with

Also associated with

Rating

Method of treating endotoxin effects with 2-methylthio-ATP and a does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of treating endotoxin effects with 2-methylthio-ATP and a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treating endotoxin effects with 2-methylthio-ATP and a will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1355955