Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Halogenated hydrocarbon doai
Patent
1992-12-16
1997-03-25
Nutter, Nathan M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Halogenated hydrocarbon doai
514745, 514747, 514751, 514762, 514763, 514764, A01N 2902, A01N 2904, A01N 2912
Patent
active
056145624
ABSTRACT:
Organoselenones of the formula
REFERENCES:
patent: 4617189 (1986-10-01), Stockel et al.
patent: 4755515 (1988-07-01), Rabinovitz
Kang et al., "A Facile Synthesis of 2-and 3-Hydroxyalkylseleno Compounds", J. Synth. Org. Chem., 2:133-135 (Feb., 1988).
Kang et al., "Linear Free Energy Relationships and Cytotoxicities of Para-Substituted 2-Haloethyl Aryl Selenides and Bis(2-chloroethyl) Selenides", J. Med. Chem. 30:597-602 (1987).
Spears, C. Paul, "Nucleophilic Selectivity Ratios of Model and Clinical Alkylating Agents by 4-(4'-Nitrobenzyl)pyridine Competition", Mol. Pharm. 19:496-504 (1980).
Kang et al., "Organoselenones Alkylation by Selenium-carbon Bond Cleavage" Abstract, Proc. Amer. Assoc. Canc. Res. 30:459 (Mar. 1989).
Kang et al., "Structure-Activity Studies on Organoselenium Alkylating Agents", J. Pharm. Sci. vol. 79, No. 1 (Jan. 1990).
Kang et al., "Phenyl Selenones: Alkyl Transfer by Selenium-Carbon Bond Cleavage", J. Med. Chem. 33:1544-1547 (1990).
Kang Sang-Ihn
Spears Colin P.
Nutter Nathan M.
The University of Sourthern California
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