Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-03-18
2009-12-01
Henley, III, Raymond J (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S731000
Reexamination Certificate
active
07625942
ABSTRACT:
A method of, or the use of compounds of the invention for, treating the cognitive impairments associated with Down syndrome, the method or use comprising treating or administering to a person with an effective amount of phenserine and isomers thereof or a pharmaceutically acceptable salt and derivatives thereof.
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Prasher et al., A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Down syndrome and Alzheimer's disease—Pilot Study, International Journal of Geriatric Psychiatry, 2002, pp. 270-278, vol. 17.
Shaw et al., Phenserine regulates translation of beta-amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development, PNAS, Jun. 19, 2001, pp. 7605-7610, vol. 98, No. 13.
Patel et al., Abstract, Phenserine, a novel acetylcholinesterase inhibitor, attenuates impaired learning of rats in a 14-unit T-maze induced by blockade of the N-methyl-D-aspartate receptor, Jan. 1998, pp. 171-176, vol. 9, No. 1.
Supplementary European Search Report, Application No. EP 05725827, dated Mar. 29, 2007, 2 pages.
Axonyx, Inc.
Drinker Biddle & Reath LLP
Henley, III Raymond J
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