Method of treating dopaminergic and GABA-nergic disorders

Details Method of treating dopaminergic and GABA-nergic disorders Method of treating dopaminergic and GABA-nergic disorders

2006-11-21

2006-11-21

Andres, Janet L. (Department: 1649)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C435S069100, C435S252300, C435S325000, C436S501000, C530S300000, C530S388220, C514S002600

Reexamination Certificate

active

07138492

ABSTRACT:
It is shown here that hedgehog proteins possess novel activities beyond phenotype specification. Using cultures derived from the embryonic day 14.5 (E14.5) rat ventral mesencephalon, we show that hedgehog is also trophic for dopaminergic neurons. Interestingly, hedgehog not only promotes dopaminergic neuron survival, but also promotes the survival of midbrain GABA-immunoreactive (GABA-ir) neurons.

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