Method of treating diseases by administering morpholino-ethylest

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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544153, A61K 31535, C07D41312

Patent

active

049525794

ABSTRACT:
The compounds and pharmaceutical compositions of Formula A, wherein Z is hydrogen or --C(O)R, where R is lower alkyl or aryl, and the pharmaceutically acceptable salts thereof, are useful as immunosuppressive agents, anti-inflammatory agents, anti-tumor agents, anti-viral agents, and anti-psoriatic agents. ##STR1##

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patent: 3868454 (1975-02-01), Johnson
patent: 3880995 (1975-04-01), Jones
patent: 3903071 (1975-09-01), Holmes
"Antitumor Activity of Derivatives of Mycophenolic Acid", Suzuki, et al., J. Antibiotics, 29(3), 275-285, 1975.
"Carbamoyl Mycophenolic Acid Ethylester, An Oral Antitumor Agent", Suzuki, et al., J. Antibiotics, 29(3), 286-291, 1975.
"Antitumor and Immunosuppressive Effects of Mycophenolic Acid", Ohsugi, et al., Cancer Research, 36, 2923-2927, 1976.
"A Gastroprotective Anti-Inflammatory Agent: The .beta.-Morpholinoethyl Ester of Niflumic Acid (Morniflumate)", Schiantarelli, et al., Agents and Actions, 14(2), 1984.

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