Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1984-06-11
1988-03-01
Brown, J. R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514824, 514929, 435 2, 435 13, 435 29, 436 63, A61K 31455, G01N 3349, C12Q 156
Patent
active
047286601
ABSTRACT:
Calcium (Ca.sup.2+) channel blockers, such as nifedipine and verapamil, are used in the treatment of thromboembolic diseases such as stroke and peripheral vascular occlusive diseases, especially arterial and venous thrombosis, vasculitis, myelofibrosis disease and hemolytic anemias. Such diseases arise from platelet hyperactivation and the Ca.sup.2+ channel blockers restore the platelets to their normal aggregation characteristics. Diagnostic procedures for detecting platelet hyperactivation and defective calcium handling/transport indicative of certain peripheral obstructive diseases using chlorotetracycline as a detectable fluorescent probe as a means of assessing a patient's response to Ca.sup.2+ channel blockers in the therapy of such diseases are also described.
REFERENCES:
patent: 4444778 (1984-04-01), Coughlin
Pumphrey et al., Am. J. Cardiol., vol. 51, pp. 541-595, Feb. 1983.
Chandler et al., cited in Chem. Abstracts vol. 88:164855a 1978.
Gelmers Acta Neurol Scand. 1984:69:232-239.
Henry, cited in Chem. Abstracts vol. 99:32910g 1983.
Henry et al., cited in Chem. Abstracts vol. 98:11308f 1983.
Ahn Yeon S.
Harrington William J.
Haynes Duncan H.
Jy Wenche
Brown J. R.
Stone Jacqueline M.
University of Miami
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