Method of treating disease with piperazine zwitterion compounds

Details Method of treating disease with piperazine zwitterion compounds Method of treating disease with piperazine zwitterion compounds

1996-02-13

1998-02-10

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

424531, 514 76, 514 77, 514564, A61K 31395, A61K 31685

Patent

active

057169594

ABSTRACT:
A substituted piperazine zwitterion composition containing, for example, as an active ingredient, HEPES (N-2 Hydroxyethylpiperazine-N'-2 Ethane Sulfonic Acid), and method useful for treatment of cancer, autoimmune, arthritis and other mammalian diseases.

REFERENCES:
patent: 4753942 (1988-06-01), O'Sullivan et al.
Synzynys et al., Chemical Abstracts, vol. 102, abstract 20432, 1985.
"Effects of In-vivo Administration of Taurine and HEPES on the Inflammatory Response in Rats" Pharmacy and Pharmacology, vol. 46, No. 9, Sep. 1994.
Norman E. Good et al, Hydrogen Ion Buffers for Biological Research, Feb. 1966, vol. 5, No. 2, Biochemistry.
The Merck Index, 12th Edition, Apr. 1996.

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