Method of treating disease states by the administration of 1.alp

Details Method of treating disease states by the administration of 1.alp Method of treating disease states by the administration of 1.alp

1984-04-03

1986-10-14

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

2603971, 2603974, 2603972, A01N 4500, A61K 3159

Patent

active

046172971

ABSTRACT:
The present invention relates to the method of treating disease states characterized by higher than normal levels of endogenously produced 1.alpha.,25 dihydroxy-cholecalciferol or conditions where there is an increased sensitivity to 1.alpha., 25 dihydroxy-cholecalciferol by administering to an organism suffering from such a disease state a pharmaceutically effective amount of the R or S epimer of 1.alpha.,25,26 trihydroxy-cholecalciferol.

REFERENCES:
patent: 4195027 (1980-03-01), DeLuca et al.
patent: 4204995 (1980-05-01), Barner et al.
patent: 4407754 (1983-10-01), Barner et al.
Arch. Biochem. Biophys., 210, (1981), article by Tanoka et al, pp. 104-109.
Helv. Chim. Acta (64) (1981) article by Patridge et al., pp. 2138-2141.

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