Method of treating diabetes with tissue-selective insulin analog

Details Method of treating diabetes with tissue-selective insulin analog Method of treating diabetes with tissue-selective insulin analog

1993-06-23

1995-08-29

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514303, 514866, A61K 3726, C07K 700

Patent

active

054460204

ABSTRACT:
Human insulin analogs are disclosed. These analogs are tissue-selective. Accordingly, pharmaceutical formulations containing the analogs of the invention provide superior clinical benefits as compared to human insulin when used in the treatment of patients suffering from diabetes. The analogs are modified at amino residue A12, A15 or A19, are different from the naturally occurring residue at said position, and are hepatoselective. Also disclosed are human insulin analogs modified at amino acid residues A12 or A14 or amino acid residues A10 and A13 different from naturally occurring residues or residues at said position or positions and are peripheral selective. DNA sequences and microorganisms comprising sequences coding for human insulin analogs are also provided. Processes for preparing the human insulin analogs are described.

REFERENCES:
Kitagawa et al. 1984, Biochemistry 23:4444-4448.
Podlecki et al, 1983 Diabetes 32:697-704.
Schartz et al. 1987 P.N.A.S. 84:6408-6411.

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