Method of treating depression with optically active isomers of 2

Details Method of treating depression with optically active isomers of 2 Method of treating depression with optically active isomers of 2

1988-11-15

1991-07-23

Rivers, Diana G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 51, A61K 31475, C07D46100

Patent

active

050343963

ABSTRACT:
A compound selected from the group consisting of optically active isomers of a racemic compound of the formula ##STR1## wherein the 3-hydrogen and 16-hydrogen are trans and ##STR2## is selected from the group consisting of ##STR3## with the --OH being .alpha. or .beta. and their non-toxic, pharmaceutically acceptable acid addition salts having antidepressant activity and an affinity for alpha.sub.2 adrenergic receptors,

REFERENCES:
patent: 4291038 (1987-09-01), Farcilli et al.
patent: 4501740 (1985-02-01), Clemence et al.
Barzaghi, et al., Arneim-Forsch./Drug Res. 36(II), nr. 10, pp. 1442-1447 (1986).
Manresa Ferreo et al., Chemical Abstracts, vol. 107(13):115839a (09/28/87).

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