Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1981-11-23
1983-05-31
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
A61K 31675
Patent
active
043860796
ABSTRACT:
A method of treating depression in humans which comprises administering orally to humans an antidepressant effective amount of a compound having the formula I.sub.1 wherein Y is alkyl of from 1 to 3 carbons, inclusive; A is ethylene or --CH.sub.2 CH(CH.sub.2 Cl)--, T and T.sub.1 are the same or different and are SR.sub.3, OR or NR.sub.1 R.sub.2 ; R is hydrogen, alkyl of from 1 through 6 carbons, aryl, aralkyl or I(a) with the proviso that when one of T or T.sub.1 is NR.sub.1 R.sub.2 then the other cannot be SR.sub.3 or OR.
REFERENCES:
patent: 2944061 (1960-07-01), Jacob et al.
patent: 3487068 (1969-12-01), Morozowich et al.
patent: 4160827 (1979-07-01), Cho et al.
Koransky, W. et al., "Phosphorylation of Nucleosides with Pyrophosphoryl Chloride", Z. Naturforsch, 17, pp. 291-295, (1962), CA, 57, 12609D.
Miki, P. et al., "A Phosphorylation of Steroids and a Dienone-Phenol Rearrangement Leading to a Secosteroidal Aldehyde which has a Strong Toxicity" Chem. Pharm. Bull. vol. 22, No. 7, pp. 1439-1450, (1974).
Cremlyn, R. J. W. et al., "A Simple Phosphorylation Procedure for Cyclic Alcohols", Synthesis, pp. 648-650, (1971).
Lacey et al., "A Simple Synthesis of Choline Alkyl Phosphates", Tetrahedron Letters, vol. 21, pp. 2017-2020, (1980).
Postescu, I. D. et al., "Characterization of Metronidazole-Phosphate; A Water Soluble Metronidazole Derivative as a Radio Sensitizer of Hypoxy Cells", Strahlentherapie, 155, pp. 358-361, (1979).
Benazet, F. et al., "Chimiotherapie", C. R. Acad., Sc. Paris, 263, Serie D-pp. 609-611, (Aug. 8, 1966).
Hoffer, M. et al., "Synthesis and Antiprotozoal Activity of 1-(3-Chloro-2-Hydroxypropyl)-Substituted Nitroimidazoles", J. Medicinal Chemistry, vol. 17, No. 9, pp. 1019-1020, (1974).
Finney, D. J., "Statistical Method in Biological Assay", Hafner Publication Co., New York, N.Y., (1952), pp. 524-530, Section 20.6.
Friedman Stanley J.
The Upjohn Company
Thierstein Joan
LandOfFree
Method of treating depression does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of treating depression, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treating depression will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2245744