Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-04-22
1996-11-26
Sayala, Chhaya D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 21, A61K 3817
Patent
active
055785689
ABSTRACT:
The present invention provides methods of treating adverse physiological effects associated with intestinal ischemia reperfusion by administering to a subject suffering from the effects of intestinal ischemia reperfusion an effective amount of a BPI protein product.
REFERENCES:
patent: 5089274 (1992-02-01), Marra et al.
patent: 5171739 (1992-12-01), Scott
patent: 5198541 (1993-03-01), Elsbach et al.
patent: 5234912 (1993-08-01), Marra et al.
patent: 5308834 (1994-05-01), Scott et al.
patent: 5334584 (1994-08-01), Scott et al.
Ammons, et al., "An N-Terminal Fragment Of Bactericidal/Permeability Increasing Protein (rBPI.sub.21) Reduces Cardiorespiratory Dysfunction Resulting From Intestinal Ischemia/Reperfusion", Annual Meeting of Professional Scientific Research Scientists, Experimental Biology 94.TM., Anaheim, California, Abstracts 1-3391, Part I, Ischemic Injury, 753 (Apr. 24-28, 1994).
Bahrami, et al., "Endotoxemia In Rats Subjected To The Haemorrhage: Effects Of Bactericidal/Permeability Increasing Protein (BPI)", Abstract Presented At Vienna International Endotoxin Society Meeting (Aug. 1992).
Bahrami, et al., "Bactericidal/Permeability-Increasing Protein (BPI) Reduces Lipopolysaccride (LPS)-Induced Cytokine Formation And Mortality In Rats", Circulatory Shock, Supplement 1, Abstract 12.25P, Vienna, Austria (May 9-13, 1993).
Boermeester, et al., "Peri-operative prophylaxis with bactericidal/permeability-increasing protein (rBPI.sub.23) prevents early postoperative derangements following partial hepatectomy", Intensive Care Medicine, vol. 20, Supplement 1, Abstract 478 (Mar. 1994).
Elsbach, et al., "Separation and Purification of a Potent Bactericidal/Permeability-increasing Protein and a Closely Associated Phospholipase A.sub.2 from Rabbit Polymorphonuclear Leukocytes", The Journal of Biological Chemistry, vol. 21, 11000-11009 (Nov. 10, 1979).
Gathiram, et al., "Changes in Lipopolysaccharide Concentrations in Hepatic Portal and Systemic Arterial Plasma During Intestinal Ischemia in Monkeys", Circulatory Shock, vol. 27, 103-109 (1989).
Gazzano-Santoro, et al., "High-Affinity Binding of the Bactericidal/Permeability-Increasing Protein and a Recombinant Amino-Terminal Fragment to the Lipid A Region of Lipopolysaccharide", Infection and Immunity, vol. 60, 4754-4761, (Nov. 1992).
Gray, et al., "Cloning of the cDNA of a Human Neutrophil Bactericidal Protein", The Journal of Biological Chemistry, vol. 264, No. 16, 9505-9509 (Jun. 1989).
Mainous, et al., "Bacterial Translocation", Pathophysiology of Shock, Sepsis, and Organ Failure, Springer-Verlag, 265-278 (1993).
Ooi, et al., "Endotoxin-neutralizing Properties of the 25 kD N-Terminal Fragment and a Newly Isolated 30 kD C-Terminal Fragment of the 55-60 kD Bactericidal/ Permeability-Increasing Protein of Human Neutrophils", J. Exp. Med., vol. 174, 649-655 (Sep. 1991).
Weiss, et al., "Cellular and Subcellular Localization of the Bactericidal/Permeability-Increasing Protein of Neutrophils", Blood, vol. 69, No. 2, 652-659 (Feb. 1987).
Yao, et al., "Effects Of Bactericidal/Permeability Increasing Protein (BPI) Against Haemorrage-Induced Endotoxemia And Mortality In Rats", Intensive Care Medicine, vol. 20, Supplement 1, Abstract 479 (Mar. 1994).
Cross, Alan S. et al., Infection and Immunity, vol. 61, No. 7, pp. 2741-2747, Jul. 1993.
Petros, Andy et al., The Lancet, vol. 338, pp. 1557-1558, 1991.
Bone, Roger C, Animals of Internal Medicine, vol. 115(6), pp. 457-469, 1991.
Glauser, M. P. et al, The Lancet, vol. 338, pp. 732-736, 1991.
Kilbourn, Robert G. et al., Jour. of the National Cancer Institute, vol. 84(11), pp. 827-831, 1992.
Natanson, Charles et al., Animals of Internal Medicine, vol. 120(9), pp. 771-783, 1994.
Ammons William S.
M esz aros K aroly M.
Sayala Chhaya D.
Xoma Corporation
LandOfFree
Method of treating conditions associated with intestinal ischemi does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of treating conditions associated with intestinal ischemi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treating conditions associated with intestinal ischemi will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1973156