Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-04-01
1995-07-25
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514342, 514420, 514468, A61K 3134, A61K 31405, A61K 3144, A61K 3155
Patent
active
054362393
ABSTRACT:
The invention relates to the treatment of antibiotic associated colitis, typically due to Clostridium difficile using the Platelet Activating Factor antagonists WEB 2170, SR 27417 or BN 52021, or the cyclooxygenase antagonist indomethacin. The PAF antagonists BN 52021 and SR 27417 and the cyclooxygenase antagonist indomethacin were effective in inhibiting the secretory effects caused by C. difficile Toxin A and by Cholera toxin.
REFERENCES:
Wallace et al., J. Lipid Mediators, 1(1), 13-23, 1989.
Fang Guodong
Fonteles Manasses C.
Guerrant Richard L.
Cintins Marianne M.
Parker Sheldon H.
Spivack Phyllis G.
The University of Virginia Patent Foundation
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