Method of treating chronic inflammatory diseases

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai

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514564, 514565, 514634, A61K 3104, A61K 31195

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active

054496888

ABSTRACT:
The present invention provides a method for treating chronic inflammatory conditions, including autoimmune diseases by administering an effective amount of an agent, such as a nitric oxide synthase inhibitor, a nitric oxide scavenger, or an inhibitor of tetrahydrobiopterin synthesis, to decrease the amount of nitric oxide present at the site of inflammation.

REFERENCES:
patent: 5028627 (1991-07-01), Kilbourn et al.
patent: 5059712 (1991-10-01), Griffith
Ialenti et al. European Journal of Pharmacology, 211 (1992) 177-182.
Wahl et al. In Molecular Pathogenesis of Periodontal Disease (1994) chapter 16 pp. 183-190.
Wahl In Inflammation: Basic Principles and Clinical Correlates, (1988) chapter 47 pp. 841-860.
Schmidt, The Lancet, (1992) vol. 339, p. 986.
Sano, J. Clin. Invest., (1992) vol. 89, pp. 97-108.
Hines, Immunomethods (1993) vol. 3, pp. 13-22.
Allen, Cytokine, (1991) vol. 3(2), pp. 98-106.
Wahl, Progress in Inflammation Research and Therapy (1991) pp. 29-34.
Remmers, Growth Factors, (1990), vol. 2, pp. 179-188.
McCartney-Francis, J. Exp. Med., (Aug. 1993) vol. 178, pp. 749-754.
Mulligan, Br. J. Pharmacology, (Dec. 1992) vol. 107 (4), pp. 1159-1162.
Umans, Eur. J. Pharmacology (1992) vol. 210, pp. 343-346.
Stefanovic-Racic, et al., "Nitric Oxide and Arthritis" in Arthritis and Rheumatism, vol. 36, No. 8 (Aug. 1993) pp. 1036-1044.
"Nitric Oxide in the Clinical Arena", The Lancet, 338, 1560-1561 (Dec. 1991).
Bernard et al., "Activated Macrophages Depress the Contractility of Rabbit Carotids via an L-Arginine/Nitric Oxide-dependent Effector Mechanism", Clin. Invest., 89, 851-860 (Mar. 1992).
Bredt et al., "Cloned and Expressed Nitric Oxide Synthase Structurally Resembles Cytochrome P-450 Reductase", Nature, 351, 714-718 (Jun. 1991).
Duarte et al., "Peripheral Analgesia and Activation of the Nitric Oxide-cyclic GMP Pathway", Journal of Pharmacology, 186, 289-293 (1990).
Hibbs et al., "L-Arginine is Required For Expression of the Activated Macrophage Effector Mechanism Causing Selective Metabolic Inhibition in Target Cells", The Journal of Immunology, 138, 550-565 (Jan. 1987).
Hughes et al., "Evidence that Endogeneous Nitric Oxide Modulates Oedema Formation Induced by Substance P", European Journal of Pharmacology, 191, 481-484 (1990).
Huot et al., "Role of Reactive Nitrogen Intermediate Production in Alveolar Macrophage-Mediated Cytostatic Activity Induced by Bleomycin Lung Damage in Rats", Cancer Research, 50, 7863-7866 (Dec. 15, 1990).
Huot et al., "Formation of Nitric Oxide Hemoglobin in Erythrocytes Co-Cultured with Alveolar Macrophages Taken From Bleomycin Treated Rats", Biochem. Biophys. Res. Commun., 182, 151-157 (Jan. 15, 1992).
Kaiser et al., "Depression of Endolthelium-Dependent Relaxation in Aorta From Rats With Brugia pahangi Lymphatic Filariasis", Circulation Research, 68, 1703-1712 (Jun. 1991).
Knowles et al., "Formation of Nitric Oxide from L-Arginine in the Central Nervous System: A Transduction Mechanism For Stimulation of the Soluble Guanylate Cyclase", Proc. Natl. Acad. Sci. USA, 86, 5159-5162 (Jul. 1989).
Kolb et al. "Suppression of Low Dose Streptozotocin Induced Diabetes in Mice by Administration of a Nitric Oxide Synthase Inhibitor", Life Sciences, 49, PL-213-PL-217 (1991).
Kroncke et al. "Activated Macrophages Kill Pancreatic Syngeneic Islet Cells Via Arginine-Dependent Nitric Oxide Generation", Biochemical and Biophysical Research Communications, 175(3), 752-758 (Mar. 1991).
Kubes et al., "Nitric Oxide: An Endogeneous Modulator of Leukocyte Adhesion", Proc. Natl. Acad. Sci. U.S.A., 88, 4651-4655 (Jun. 1991).
Kubrina et al., "Formation of Nitric Oxide in Animal Tissues During Inflammatory Process", Biull Eksp. Biol. Med., 107 (1) 31-33 (Jan. 1989).
Lancaster, "Nitric Oxide in Cells", American Scientist, 80, 248-259 (May-Jun. 1992).
Lyons et al. "Molecular Cloning and Functional Expression of an Inducible Nitric Oxide Synthase from a Murine Macrophage Cell Line", The Journal of Biological Chemistry, 267(9), 6370-6374 (Mar. 1992).
MacIntyre et al., "Osteoclastic Inhibition: An Action of Nitric Oxide not Mediated by Cyclic GMP", Proc. Natl. Acad. Sci. U.S.A., 88, 2936-2940 (Apr. 1991).
McCall et al., "Induction of Nitric Oxide Synthase in Rat Peritoneal Neutrophils and its Inhibition by Dexamethasone", European Journal of Immunology, 21, 2523-2527 (1991).
Moncada et al., "Biosynthesis of Nitric Oxide From L-Arginine", Biochemical Pharmacology, 38(11), 1709-1715 (1989).
Murray et al., "L-Arginine-Dependent Reactive Nitrogen Intermediates and the Antimicrobial Effect of Activated Human Mononuclear Phagocytes", Journal of Infectious Diseases, 165, 513-517 (1992).
O'Connor et al., "Glucocorticoids Inhibit the Induction of Nitric Oxide Synthase and the Related Cell Damage in Adenocarcinoma Cells", Biochim. Biophys. Acta., 1097, 227-231 (1991).
Palmer et al., "L-Arginine is the Physiological Precursor For the Formulation of Nitric Oxide in Endothelium-Dependent Relaxation," Biochem. Biophys. Res. Commun., 153(3), 1251-1256 (Jun. 1988).
Radomski et al., "Glucocortoids Inhibit the Expression of an Inducible but not the Constitutive, Nitric Oxide Synthase in Vascular Endothelial Cells", Proc. Natl. Acad. Sci. U.S.A., 87, 10043-10047 (Dec. 1990).
Shultz et al., "Synthesis and Action of Nitric Oxide in Rat Glomerular Mesangial Cells", Am. J. Physiol., 261, F600-F606 (1991).
Snyder et al., "Biological Roles of Nitric Oxide", Scientific American, 68-77 (May 1992).
Stadler et al., "Articular Chondrocytes Synthesize Nitric Oxide in Response to Cytokines and Lipopolysaccharide", Journal of Immunology, 147(11), 3915-3920 (Dec. 1991).
Tare et al., "Hyperpolarization and Relaxation of Arterial Smooth Muscle Caused by Nitric Oxide Derived from the Endothelium", Nature, 346, 69-71, 1990.
Toda et al., "Endothelium-derived Relaxing Factor (EDRF)", Nippon Yakurigaku Zasshi, 95(6), 295-308, Jun. 1990.
Weissman et al., "N.sup.G -Nitro-L-Arginine Enhances Neuronal Death Following Transient Forebrain Ischemia In Gerbils", Neuroscience Letters, 146, 139-142 (1992).
Xie et al., "Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages", Science, 256, 225-228 (Apr. 1992).
Zielasek et al., "Production of Nitrite by Neonatal Rat Microglial Cells/Brain Macrophages", Cellular Immunology, 141, 111-120 (1992).
Corbett et al., Diabetes, vol. 41, Apr. 1992, pp. 552-556.
Mulligan et al., Medline Abstract No. 93104992, 1992.
Umans et al., Medline Abstract No. 92307003, 1992.

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