Method of treating chronic fatigue syndrome using an opiate rece

Details Method of treating chronic fatigue syndrome using an opiate rece Method of treating chronic fatigue syndrome using an opiate rece

1989-11-08

1991-05-07

Robinson, Allen J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3144

Patent

active

050137395

ABSTRACT:
Chronic herpes viral infections, including chronic genital herpes caused by the herpes simplex virus, Type 2, and chronic infections due to the Epstein-Barr virus, chronic fatigue syndrome, chronic inflammatory connective tissue disease, including rheumatoid arthritis and systemic lupus erythematous and related diseases, and multiple sclerosis are treated by the administration via a pharmacologically effective route of an essentially pure opiate receptor antagonist, preferably an essentially pure opiate receptor antagonist exhibiting a substantially higher blocking effectiveness against Mu opiate receptor sites than against Delta receptor sites, exemplified by naltrexone and naloxone, at a low dose concentration, corresponding to about 1-10 mg per day for naltrexone, at which concentration Delta blocking activity is small, while Mu blocking activity is significant.

REFERENCES:
patent: 4537878 (1985-08-01), Plotnikoff
patent: 4857533 (1989-08-01), Sherman et al.
patent: 4863928 (1989-10-01), Atkinson
Prieto, J. et al., Naloxone Reversable Monocyte Dysfunction in Patients with Chronic Fatigue Syndrome, Scand J Immonol 30(1):13-20 (1989) (Abstract).

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