Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-10-14
1997-01-07
Jordan, Kimberly
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514292, 514810, 514811, 514812, 514813, A61K 3155, A61K 3144
Patent
active
055917380
ABSTRACT:
A method of treating a chemical dependency disorder, an abuse syndrome or a combination thereof in a mammal in need thereof, which entails administering, to a mammal in need thereof, an amount of a .beta.-carboline alkaloid, hydrolyzable derivative thereof or pharmaceutically-acceptable salt thereof effective to treat said chemical dependency disorder, abuse syndrome or a combination thereof in the mammal.
REFERENCES:
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Gunn, J. A., "Relations Between Chemical Constitution, Pharmacological ctions, and Therapeutic Uses, in the Harmine Group of Alkaloids", The Pharmacological Laboratory, University of Oxford, Mar. 14, 1935, pp. 379-383, 395-396.
Slotkin, Theodore A. and DiStefano, Victor; "A Model of Harmine Metabolism in the Rat", The Journal of Pharmacology and Experimental Therapeutics, Department of Pharmacology, University of Rochester, Rochester, New York, The Williams & Wilkins Co., vol. 174, No. 3, 1970, pp. 456-462.
Ho, Beng T. et al, "Metabolish of Harmaline in Rats", Biochemical Pharmacology, vol. 20, pp. 1313-1319, Pergamon Press, 1971, Great Britain.
Slotkin, Theodore A. et al, "Blood Levels and Urinary Exretion of Harmine and its Metabolites in Man and Rats", The Jurnal of pharmacology and Experimental Therapeutics, 1970, The William & Wilkins Co., vol. 173, No. 1, pp. 26-30, USA.
Slotkin, Theodore and DiStefano, Victor, "Urinary Metaboliytes of Harmine in the Rat and Theri Inhibition of Monoamine Oxidase" Biochemical Pharmacology, vol. 19, pp. 125-131, Pergamon Press, 1970, Great Britain.
Zetler, G. et al, "Pharmacokinetic in the Rat of the hallucinogenic Alkaloids Harmine and Harmaline", Naunyn-Schmiedeberg's Arch. Pharmacol. Springer-Verlag, 1974, pp. 285, 273-292.
Glick, S. D., et al, "Effects of iboga Alkaloids on Morphine and Cocaine Self-Administration in Rsats: Relationship to Tremorigenuc Effects and to Effects on Dopamine Release in Nucleus Accumbens and Striatum", Brain Reseach, Elsevier Science B. V., Jun. 7, 1994, pp. 14-22.
Jordan Kimberly
NDA International, Inc.
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