Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Reexamination Certificate
2007-12-06
2009-02-24
Gitomer, Ralph (Department: 1657)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
C435S069200
Reexamination Certificate
active
07494784
ABSTRACT:
The present invention relates to methods of identifying agents which modulate the activity of PIPKIγ661. Methods of using such agents to prevent or treat a cell migration-mediated condition or disease in a subject are also provided.
REFERENCES:
patent: 4736866 (1988-04-01), Leder et al.
patent: 4745051 (1988-05-01), Smith et al.
patent: 4870009 (1989-09-01), Evans et al.
patent: 4879236 (1989-11-01), Smith et al.
patent: 5166320 (1992-11-01), Wu et al.
patent: 6015893 (2000-01-01), Cance et al.
patent: 6465495 (2002-10-01), Castelhano et al.
patent: 7097993 (2006-08-01), Anderson et al.
patent: 7329504 (2008-02-01), Anderson et al.
patent: 2003/0114400 (2003-06-01), Bennett et al.
patent: 2004/0197792 (2004-10-01), Whyte et al.
patent: 2005/0125852 (2005-06-01), Caenepeel et al.
patent: 0 264 166 (1988-04-01), None
patent: 0 362 179 (1990-04-01), None
patent: WO 90/13646 (1990-11-01), None
patent: WO 97/19954 (1997-06-01), None
Anderson et al., “Phosphatidylinositol Phosphate Kinases, a Multifaceted Family of Signaling Enzymes”,J. Biological Chemistry, vol. 274, No. 15, 1999 (p. 9907-9910).
Barry et al., :The RhoA-dependent assembly of focal adhesions in Swiss 3T3 cells is associated with increased tyrosine phosphorylation and the recruitment of both pp125FAK and protein kinase C-ē to focal adhesions,Journal of Cell Science, vol. 107, 1994 (pp. 2033-2045).
Berditchevski et al., “A Novel Link between Integrins, Transmembrane-4 Superfamily Proteins (CD63 and CD81), and Phosphatidylinositol 4-Kinase”,J. Biological Chemistry, vol. 272, No. 5, 1997 (pp. 2595-2598).
Burridge et al., “Focal Adhesions, Contractility, and Signaling”,Annu. Rev. Cell Dev. Biol., vol. 12, 1996 (pp. 463-519).
Cary et al., “Focal Adhesion Kinase In Integrin-Mediated Signaling”,Frontiers in Bioscience, vol. 4 (d102-113), 1999 (pp. 1-24).
Chong et al., “The Small GTP-Binding Protein Rho Regulates a Phosphatidylinositol 4-Phosphate 5-Kinase in Mammalian Cells”,Cell, vol. 79, 1994 (pp. 507-513).
Chrzanowska-Wodnicka et al., “Tyrosine phosphorylation is involved in reorganization of the actin cytoskeleton in response to serum of LPA stimulation”,Journal of Cell Science, vol. 107, 1994 (pp. 3643-3654).
Cobb et al., “Stable Association of pp60srcand pp59fynwith the Focal Adhesion-Associated Protein Tyrosine Kinase, pp125FAK”,Molecular and Cellular Biology, vol. 14, No. 1, 1994 (pp. 147-155).
Critchley, David R., “Focal adhesions-the cytoskeletal connection”,Current Opinion in Cell Biology, vol. 12, 2000 (pp. 133-139).
Dipaolo et al., “Recruitment and regulation of phosphatidylinositol phosphate kinase type 1γby the FERM domain of talin”,Nature, vol. 420, 2002 (pp. 85-93).
Gilmore et al., “Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate”,Nature, vol. 381, 1996 (pp. 531-535).
Ishihara et al., “Type I Phosphatidylinositol-4-phosphate 5-Kinases”,Journal Biological Chemistry, vol. 273, No. 15, 1996 (pp. 8741-8478).
Janney, Paul A., “Phosphoinositides and Calcium as Regulators of Cellular Actin Assembly and Disassembly”,Annu. Rev. Physiol., vol. 56, 1994 (pp. 169-191).
Kunz et al., “The Activation Loop of Phosphatidylinositol Phosphate Kinases Determines Signaling Specificity”,Molecular Cell, vol. 5, 2000 (pp. 1-11).
Ling et al., “Type I65phosphatidylinositol phosphate kinase targets and regulates focal adhesions”,Nature, vol. 420, 2002 (pp. 89-93).
Martel et al., “Conformation, Localization, and Integrin Binding of Talin Depend on Its Interaction with Phosphoinositides”,J. Biol. Chem., vol. 276, No. 24, 2001 (pp. 21217-21227).
McNamee et al., “Adhesion to Fibronectin Stimulates Inositol Lipid Synthesis and Enhances PDGF-induced Inositol Lipid Breakdown”,J. Cell Biology, No. 121, 1993 (pp. 673-678).
Parsons et al., “Focal Adhesion Kinase:a regulator of focal adhesion dynamics and cell movement”,Oncogene, No. 19, 2000 (pp. 5606-5613).
Ridley et al., “Signal transduction pathways regulating Rhomediated stress fibre formation:requirement for a tyrosine kinase”,The EMBO Journal, vol. 13, No. 11, 1994 (pp. 2600-2610).
Schaller et al., “Autophosphorylation of the Focal Adhesion Kinase, pp125FAK, Directs SH2-Dependent Binding of pp60src”,Molecular and Cellular Biology, vol. 14, No. 3, 1994 (pp. 1680-1688).
Schaller, Michael D., “Biochemical signals and biological responses elicited by the focal adhesion kinase”,Biochmica et Biophysica Acta, vol. 1540, 2001 (pp. 1-21).
Schaller et al., “Complex Formation with Focal Adhesion Kinase:A Mechanism to Regulate Activity and Subcellular Localization of SRC Kinases”,Molecular Biology of the Cell, vol. 10, 1999 (pp. 3489-3505).
Schwartz et al., “Networks and crosstalk:integrin signalling spreads”,Nature Cell Biology, vol. 4, 2002 (pp. E65-E68).
Steimle et al., “Polyphosphoinositides Inhibit the Interaction of Vinculin with Actin Filaments”, Journal of Biological Chemistry, vol. 274, No. 26, 1999 (pp. 18414-18420).
Anderson Richard A.
Ling Kun
Foley & Lardner LLP
Gitomer Ralph
Wisconsin Alumni Research Foundation
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