Method of treating CD4+ T cell lymphopenia in immuno-compromised

Details Method of treating CD4+ T cell lymphopenia in immuno-compromised Method of treating CD4+ T cell lymphopenia in immuno-compromised

1996-06-14

1998-03-17

Cunningham, Thomas M.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435188, 435227, 514 4, 514 21, 514 46, A61K 3843, C12N 900, C12N 978

Patent

active

057285608

ABSTRACT:
The present invention is directed to methods of treating CD4+ T cell lymphopenia in HIV-infected patients. The methods include administering an effective mount of adenosine deaminase or related enzymatic material to a patient in need thereof. In preferred aspects of the invention, the method is employed in conjunction with HIV-infected patients having CD4+ T cell levels of less than about 200/.mu.l. Effective amounts of the enzyme range from about 5 to about 50 IU/kg/week. In one particularly preferred aspect of the invention, the adenosine deaminase is conjugated to one or more strands of polyethylene glycol to prolonged activity in vivo.

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