Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Cancer cell or component thereof
Patent
1996-12-26
2000-03-07
Burke, Julie
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Cancer cell or component thereof
424 9321, 424 937, 424 851, 435 695, 435 701, 435375, 435384, 435369, 435405, 435406, 536 235, A61K 3539, C07H 2104
Patent
active
060336749
ABSTRACT:
The present invention provides a method of treating cancer comprising (a) obtaining a tumor cell line, (b) modifying the tumor cell line to render it capable of producing an increased level of a cytokine relative to the unmodified tumor cell line, and (c) administering the tumor cell line to a mammalian host having at least one tumor that is the same type of tumor as that from which the tumor cell line was obtained, wherein the tumor cell line is allogeneic and is not MHC-matched to the host. The present invention also provides a pancreatic tumor cell line, a method and medium for obtaining such a tumor cell line, and a composition comprised of cells of a purified pancreatic tumor cell line.
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Jaffee Elizabeth M.
Levitsky Hyam I.
Pardoll Drew M.
Burke Julie
Johns Hopkins University School of Medicine
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