Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Cancer cell or component thereof
Reexamination Certificate
2008-03-07
2010-06-22
Helms, Larry R. (Department: 1643)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Cancer cell or component thereof
C435S001100
Reexamination Certificate
active
07740872
ABSTRACT:
The present invention relates to a delipidation method employing a solvent system useful for extracting lipids from cancer cells, thereby creating a modified cancer cell particle. Upon delipidation of the cancer cells, a portion of the cancer cell antigens remain intact. These exposed antigens, or epitopes, foster and promote antibody production. The resulting modified cancer cell particle, or portions of the cancer cell, initiate a positive immunogenic response when administered to an animal or human and help to treat, prevent or delay the onset of cancer. The present invention provides autologous and heterologous vaccine compositions comprising the modified cancer cell with a pharmaceutically acceptable carrier. The present invention provides method of administering these vaccines to treat, prevent or delay the onset of cancer.
REFERENCES:
patent: 6991727 (2006-01-01), Bomberger et al.
patent: 7033500 (2006-04-01), Bomberger et al.
patent: 7166223 (2007-01-01), Bomberger et al.
patent: 7195710 (2007-03-01), Bomberger et al.
patent: 7297261 (2007-11-01), Bomberger et al.
patent: 7297262 (2007-11-01), Bomberger et al.
patent: 7361360 (2008-04-01), Kitabwalla et al.
patent: 7364658 (2008-04-01), Bomberger et al.
patent: 7402246 (2008-07-01), Bomberger et al.
patent: 7407662 (2008-08-01), Cham et al.
patent: 7407663 (2008-08-01), Cham et al.
patent: 7439052 (2008-10-01), Cham
patent: 2003/0104350 (2003-06-01), Bomberger et al.
patent: 2003/0119782 (2003-06-01), Cham
patent: 2003/0127386 (2003-07-01), Bomberger et al.
patent: 2003/0133929 (2003-07-01), Cham
patent: 2004/0106556 (2004-06-01), Zhu et al.
patent: 2004/0202676 (2004-10-01), Rybudo et al.
patent: 2004/0256307 (2004-12-01), Bomberger et al.
patent: 2005/0004004 (2005-01-01), Bellotti et al.
patent: 2005/0016912 (2005-01-01), Bomberger et al.
patent: 2007/0212376 (2007-09-01), Cham
patent: 2008/0083671 (2008-04-01), Bomberger et al.
patent: 2008/0149572 (2008-06-01), Bomberger et al.
patent: 2008/0203022 (2008-08-01), Bomberger et al.
patent: 2008/0220016 (2008-09-01), Cham et al.
patent: 2008/0220017 (2008-09-01), Cham et al.
patent: 2008/0267997 (2008-10-01), Cham et al.
patent: 2009/0017069 (2009-01-01), Akeefe et al.
patent: 2009/0028902 (2009-01-01), Cham et al.
patent: 2009/0032468 (2009-02-01), Bomberger et al.
Kitabwalla, Ansari, Villinger, Akeefe, Conner, Mayne, and Hildreth. Delipidated retroviruses as potential autologous therapeutic vaccines—a pilot experiment. Experimental Biology and Medicine, 2008, vol. 233, pp. 732-740.
“Stedman's Medical Dictionary”,27th Edition, Vaccine Definition2000.
Bachmann, M. F. et al., “Recall Proliferation Potential of Memory CD8+ T Cells and Antiviral Protection”,Journal of Immunology,175 2005 , 4677-4685.
Efferson, C. L. et al., “Stimulation of Human T Cells by an Influenza A Vector Expressing a CTL Epitope from the HER-2
eu Protooncogene Resuls in Higher Numbers of Antigen-specific TCRhi Cells than Stimulation with Peptide. Divergent Roles of IL-2 and IL-15”,Anticancer Research,25 2005 , 715-724.
Fields, et al., “Murine Dendritic Cells Pulsed With Whole Cell Tumor Lysates Mediate Potent Antitumor Immune Responses in Vitro and in Vivo,”Proc. Natl. Acad. Sci. USA, vol. 95, pp. 9482-9487 (1998).
Kitabwalla, et al., “Enhancement of Cell Mediated Immune Responses Using Lipid Depleted Lentivirus as Immunogen: A Novel Approach for Inducing Recognition of New Viral Epitopes,”Vaccine, vol. 23, pp. 4666-4677 (2005).
Wheeler, Cosette M. “Preventive Vaccines for cervical Cancer”,Salud Publica de Mexico, 39(4) 1997.
Unpublished U.S. Appl. No. 12/203,551, filed Sep. 3, 2008.
Akeefe Hassibullah
Kitabwalla Moiz
Eli Lilly and Company
Gussow Anne M.
Helms Larry R.
Kilpatrick & Stockton LLP
LandOfFree
Method of treating cancer cells to create a modified cancer... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of treating cancer cells to create a modified cancer..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treating cancer cells to create a modified cancer... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4247210