Method of treating cancer by conjunctive therapy with N,N'-bis[3

Details Method of treating cancer by conjunctive therapy with N,N'-bis[3 Method of treating cancer by conjunctive therapy with N,N'-bis[3

1995-06-02

1997-07-08

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 11, 514 32, 514 33, 514410, 514674, A61K 3170, A61K 3800, A61K 3140, A61K 3113

Patent

active

056461240

ABSTRACT:
The present invention relates to a method of treating a patient suffering from a neoplastic disease state comprising administering to said patient an effective antineoplastic amount of N,N'-bis[3-(ethylamino)propyl]-1,7-heptanediamine in conjunctive therapy with an effective antineoplastic amount of a cytotoxic agent selected from the group consisting of an antineoplastic vinca alkaloid, an antineoplastic antibiotic, an antineoplastic antimetabolite and an antineoplastic platinum coordination complex, wherein a synergistic antineoplastic effect results.

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patent: 5109024 (1992-04-01), Prakash et al.
Hall, M. J., et al., J. Antimicrobial Chemotherapy, vol. 11, 427-433, 1983.
The Merck Index, 9th Edition, Merck & Co., Inc., Rahway, N.J., p. 1281-1282, 1976.
Prakash, et al., Anticancer Research, vol. 10(5A):1281-1288 (Sep.-Oct. 1990).
Bergeron, R.J., Acc. Chem. Res, vol. 19, 105-113 (1986).
P. Calabresi et al., "Chemotherapy of Neoplastic Diseases", Goodman & Gillman's The Pharmaceutical Basis of Therapeutics, 8th Ed., pp. 1202-1263, (1990).
The Merck Index, 9th Ed., Merck & Co., Inc., Rahway, N.J. pp. 171, 368, 371, 456, 807 and 808 (1976).

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