Method of treating cancer by conjunctive therapy with N,N'-bis[3

Details Method of treating cancer by conjunctive therapy with N,N'-bis[3 Method of treating cancer by conjunctive therapy with N,N'-bis[3

1995-06-02

1997-06-03

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Inorganic active ingredient containing

Heavy metal or compound thereof

514492, 514674, A61K 3324, A61K 3128, A61K 3113

Patent

active

056352182

ABSTRACT:
The present invention relates to a method of treating a patient suffering from a neoplastic disease state comprising administering to said patient an effective antineoplastic amount of N,N'-bis[3-(ethylamino)propyl]-1,7-heptanediamine in conjunctive therapy with an effective antineoplastic amount of a cytotoxic agent selected from the group consisting of an antineoplastic vinca alkaloid, an antineoplastic antibiotic, an antineoplastic antimetabolite and an antineoplastic platinum coordination complex, wherein a synergistic antineoplastic effect results.

REFERENCES:
patent: 4048324 (1977-09-01), Kohn
patent: 4719313 (1988-01-01), Gerhart et al.
patent: 5109024 (1992-04-01), Prakash et al.
The Merck Index, 11th ED, 1989, Merck & Co, Inc., Rahway, N.J., pp. 276 and 361.
Hall, M. J., et al., J. Antimicrobial Chemotherapy, vol. 11, 427-433, 1983.
The Merck Index, 9th Edition, Merck & Co., Inc., Rahway, N.J., pp. 1281-1282, 1976.
Prakash, et al., Anticancer Research, vol. 10(5A):1281-1288 (Sep.-Oct. 1990).
Bergeron, R.J., Acc. Chem. Res., vol. 19, 105-113 (1986).
P. Calabresi et al., "Chemotherapy of Neoplastic Diseases", Goodman & Gillman's The Pharmaceutical Basis of Therapeutics, 8th Ed., pp. 1202-1263, (1990).

Affiliated with

Also associated with

Rating

Method of treating cancer by conjunctive therapy with N,N'-bis[3 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of treating cancer by conjunctive therapy with N,N'-bis[3, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treating cancer by conjunctive therapy with N,N'-bis[3 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-389634