Method of treating bronchoconstriction with 1,3-unsymmetrical st

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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544267, 544273, A61K 3152, C07D47306

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active

050325930

ABSTRACT:
1,3-Alkyl substituted-8-phenylxanthines in which the straight chain alkyl substituents are different and pharmaceutically acceptable salts of such compounds are disclosed. Preferred compounds have 1-n-propyl-3-methyl and 1-methyl-3-n-propyl substituents. The compounds are potent bronchodilators.

REFERENCES:
patent: 4089959 (1978-05-01), Diamond
patent: 4593095 (1986-06-01), Snyder et al.
patent: 4612315 (1986-09-01), Jacobson et al.
patent: 4783530 (1988-11-01), Rzeszotarski et al.
Chasin et al., "Advances in Cyclic Nuceotide Research," vol. 7, ed. Greengard et al., Raven Press, N.Y. (1976), pp. 225-264.
Wells et al., J. Med. Chem., vol. 24, No. 8, pp. 954-958 (08/81).
Fredholm et al., European J. Pharmacology, vol. 81, pp. 673-676 (1982).
Persson, Agents Actions, vol. 13, (suppl.), pp. 115-129 (1983).
Bruns et al., Proc. Natl. Acad. Sci. U.S.A., vol. 80, pp. 2077-2080 (04/83).
Rall, "The Pharmacological Basis of Therapeutics", 7th ed., Gilman, et al., ed., MacMillan Publishers, N.Y. (1985), Chap. 25, pp. 589-603.
Hamilton et al., J. Med. Chem., vol. 28, No. 8, pp. 1071-1079 (08/85).
Persson et al., Life Sciences, vol. 38, No. 12, pp. 1057-1072 (1986).
Daly et al., J. Med. Chem., vol. 29, No. 7, pp. 1305-1308 (7/86).
Bruns et al., Molecular Pharmacology, vol. 29, pp. 331-346 (1986).
Daly et al., J. Med. Chem., vol. 28, pp. 487-492 (1985).
Hamilton et al., J. Med. Chem., vol. 30, No. 1, pp. 91-96 (01/87).

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