Method of treating bone disease with pyridine, carboxamide and c

Details Method of treating bone disease with pyridine, carboxamide and c Method of treating bone disease with pyridine, carboxamide and c

1994-04-01

1996-06-11

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514563, 514535, 514539, A61K 3144, A61K 31195, A61K 3124

Patent

active

055256180

ABSTRACT:
Treatment of osteopathic comprising administering as an active ingredient a compound represented by the following formula (I), (II) or (III): ##STR1##

REFERENCES:
patent: 5070108 (1991-12-01), Margolis
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Pharmaceutical Sciences (1980), MACK Publishing Co. pp. 420-427.
Tamura et al., "Synthetic Retinoids, Retinobenzoic Acids, Am80, Am580 and Ch55 Regulate Morphogenesis in Chick Limb Bud," Cell Differentiation and Development, vol. 32, 1990, pp. 17-26.
Mark et al., "Effects of Retinoids on Tooth Morphogenesis and Cytodifferentiations, in vitro," Int. J. Dev. Biol. vol. 36, 1992, pp. 517-526.
Oikawa et al., "Three Novel Synthetic Retinoids, Re 80, Am 580 and Am 80, All Exhibit Anti-Angiogenic Activity In Vivo," European Journal of Pharmacology, vol. 249, 1993, pp. 113-116.
Gianni et al., "Effects of Synthesis Retinoids and Retinoic Acid Isomers on the Expression of Alkaline Phosphatase in F9 Teratocarcinoma Cells," Biochemical and Biophysical Research Communications, vol. 196, No. 1, 1993, pp. 253-259.
R. P. J. O'Neill et al., "Effect of Retinoic Acid on the Resorptive Activity of Chick Osteoclasts In Vitro," Bone, 13, pp. 23-27 (1992).
H. Gollnick et al., "Retinoids: An Overview of Pharmacokinetics and Therapeutic Value," Methods in Enzymology, vol. 190, pp. 291-304. (1990).

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