Method of treating autoimmune and/or viral-induced diseases that

Details Method of treating autoimmune and/or viral-induced diseases that Method of treating autoimmune and/or viral-induced diseases that

1994-01-06

1997-08-26

Smith, Lynette F.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

424 851, 530350, A61K 39395, A61K 4505, C07K 100, C07K 1400

Patent

active

056608284

ABSTRACT:
A method to block cytolytic activity of CD8 phenotype T cells using an effective amount of a complement-fixing anti CD8 antibody is described. The anti CD8 antibody may be used to treat patients with immunopathologic disorders induced by viruses or (autoimmune diseases) such as multiple sclerosis, viral or post-viral polyneuropathy, viral or post-viral myocarditis, insulitis, encephalomyelitis, myositis, synovitus, and arthritis.

REFERENCES:
patent: 4695459 (1987-09-01), Steinman et al.
Rodriguez, et al., 1987, "Treatment of TMEV Induced Demyelination . . . " Neurology 37:344, Abstract #10.
Sarmiento, et al., 1980, "IgG or IgM Monoclonal Antibodies . . . " J. Immunol. 125: 2665-2672.
Rodriguez, et al., 1986, "Susceptibility to Theiler's Virus-Induced . . . " J. Exp. Med. 163: 620-631.
Huber, et al., 1984, "In Vitro Culture of Coxsackievirus Group B . . . " Infect. and Imm. 43(2): 567-573.
Rodriguez, et al, 1986, "Partial Suppression of . . . " Neurology 36: 964-970.
Friedman, et al, 1987, "Monoclonal Anti-I-A Antibody . . . " J. Virol. 61(3): 898-903.
Sriram, et al, 1986, "Treatment of Established . . . " J. Immunol. 136(12): 4464-4469.
Clatch, et al., 1985, "Theiler's Murine Encephalomyelitis Virus . . . ," Journal of Immunology vol. 135(2): 1408-1414.

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