Method of treating atherosclerosis or restenosis using microtubu

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514824, A61K 31335, A61K 3308

Patent

active

056166087

ABSTRACT:
The present invention is a method of preventing or reducing atherosclerosis or restenosis, and a pharmaceutical preparation used therefor. In particular, it is a method of preventing or reducing atherosclerosis or restenosis after arterial injury by treatment with a low dose of a microtubule stabilizing agent such as taxol or a water soluble taxol derivative. The low dose used in the present invention prevents artery blockage while minimizing any negative side effects associated with the drug.

REFERENCES:
patent: 5157049 (1992-10-01), Haugwitz et al.
patent: 5223269 (1993-06-01), Liefens
Katsuda, et al, (1988) "Inhibitory Effect of Dimethyl Sulfoxide on the Proliferation of Cultured Arterial Smooth Muscle Cells: Relationship to the Cytoplasmic Microtubles", Exp & Mol. Path. 48:41-58.
Bard et al.: "Normolipemic Activities of Acrylophenone Derivatives with Antimicrotubular Properties"; Meth. and Find. Clin. Pharmacol., 1985, vol. 7, No. 4, pp. 183-187.
Chaldakov G. N., "Antibulins --A New Therapeutic Approach for Atherosclerosis?"; Atherosclerosis, 1982, vol. 44, pp. 385-390.
L ovquist et al.; "Pathophysiological Mechanism for Restenosis Following Coronary Antioplasty: Possible Preventive Alternatives"; J. of Int. Med., 1993, vol. 233, pp. 215-226.
Jesee V. Currier, et al.; "Colchicine Inhibits Restenosis After Iliac Angioplasty In The Atherosclerotic Rabbit"; Supplement II Circulation, 1989, vol. 80, pp. II-66.
G. Godeau, et al.; "Effect Of Colchicine on Atherosclerosis-III. Study Of Dermal Elastic Fibers By Quantitative Histochemistry, Automated Image Analysis"; Clinical Physiology and Biochemistry, 1985, vol. 3, pp. 234-239.
William Hollander, et al.; "Effects Of Anticalcifying And Antifibrobrotic Drugs On Pre-Established Atherosclerosis In The Rabbit"; Atherosclerosis, 1979, vol. 33, pp. 111-123.
James H. O'Keefe, Jr., et al.; "Ineffectiveness Of Colchicine For The Prevention Of Restenosis After Coronary Angioplasty"; Journal of the American College of Cardiology, 1992, vol. 19, No. 7, pp. 1597-1600.
David W. M. Muller, et al.; "Colchicine and Antineoplastic Therapy For The Prevention Of Restenosis After Percutaneous Coronary Interventions"; Journal of the American College of Cardiology, 1991, vol. 17, No. 6, pp. 126B-31B.
Eric K. Rowinsky, et al.; "Taxol: A Novel Investigational Antimicrotubule Agent"; Journal of the National Cancer Institute, 1990, vol. 82, pp. 1247-1259.
Gordon A. A. Ferns, et al.; "Inhibition of Neointimal Smooth Muscle Accumulation After Angioplasty by an Antibody to PDGF"; Science, 1991, vol. 253, pp. 1129-1132.
P.B. Schiff, et al; "Promotion of Microtubule Assembly In Vitro By Taxol"; Nature, 1979, vol. 277, pp. 665-667.
P. B. Schiff, et al; "Taxol Assemblies Tubulin in the Absence of Exogeneous Guanosine 5'-Triphosphate or Microtubule-Associated Proteins"; Biochemistry, 1981, vol. 20, pp. 3247-3252.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method of treating atherosclerosis or restenosis using microtubu does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of treating atherosclerosis or restenosis using microtubu, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treating atherosclerosis or restenosis using microtubu will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-539398

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.