Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-10-15
1991-07-09
Friedman, Sidney J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31415
Patent
active
050306456
ABSTRACT:
(S)-.alpha.-fluoromethylhistidine, a potent, selective, mechanism-based inhibitor of mammalian histidine carboxylase, the enzyme responsible for biosynthesis of histamine in mammals, is useful in the treatment of asthma.
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Agricl. Biol. Chem. 52 891-3 (1988).
Agric. Biol. Chem. 52(6), 1607.1608 (1988).
Immunology 65 433-36 (1988).
Friedman Sidney J.
Merck & Co. , Inc.
Pfeiffer Hesna J.
Speer Raymond M.
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