Method of treating arthritis, including rheumatoid arthritis, wi

Details Method of treating arthritis, including rheumatoid arthritis, wi Method of treating arthritis, including rheumatoid arthritis, wi

1989-06-16

1991-06-25

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

600 3, 600 4, 534 10, A61K 4300, A61N 510

Patent

active

050265385

ABSTRACT:
.sup.166 Holmium in a carrier metallic hydroxide aggregate is disclosed for the treatment of arthritis and, in particular, rheumatoid arthritis. The compound disclosed preferably has a particle size of 1 to 40 microns, Beta energy emissions in the range of 1.76-1.84 MeV, low levels of gamma ray emissions and a radioactive half-life of 26.8 hours. The preferred metallic hydroxide is selected from the group consisting of Ferric Hydroxide, Aluminum Hydroxide, Bismuth Hydroxide, Chromium Hydroxide, Cupric Hydroxide, Manganese Hydroxide and Stannous Hydroxide. Methods are also disclosed for the preparation of the compound, as well as for the methods of its administration to a patient in need thereof.

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Sledge et al., Radiation Synovectomy, No. 152 (1984), pp. 37-40.
Sledge et al., Arthritis and Rheumatism, vol. 20(7), pp. 1334-1342 (1977).

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