Method of treating arrhythmia with diarylbutanolamines

Details Method of treating arrhythmia with diarylbutanolamines Method of treating arrhythmia with diarylbutanolamines

Filed on

1976-10-12

Date issued

1977-09-20

Examiner

Moyer, Donald B.

Patent Class

Drug, bio-affecting and body treating compositions

SubClass

Antigen, epitope, or other immunospecific immunoeffector

SubSubClass

Recombinant or stably-transformed bacterium encoding one or...

Other Related Categories

42424857, 424267, 424274, 424329, A61K 31135, A61K 31535, A61K 31445, A61K 3114, A61K 3140

Type

Patent

Status

active

Patent number

040498271

Description

ABSTRACT:
4,4-Diphenyl-2-hydroxybutylamines are prepared by condensing amines with 1,2-epoxy-4,4-diphenylbutanes. The new compounds exist in the free base form, as acid addition salts and quaternary ammonium salts, and exhibit antiarrhythmic activity.

REFERENCES:
patent: 2891890 (1959-06-01), Adamson
patent: 3395146 (1968-07-01), Satzinger
patent: 3412091 (1968-11-01), Moffett
patent: 3433836 (1969-03-01), Petracek
patent: 3439035 (1969-04-01), Grisar et al.
patent: 3987201 (1976-10-01), Molloy
Blank et al., J. Med. Chem. pp. 271-276 (1969).
Chemical Abstracts: Benoit et al., vol. 46, p. 476 (1952); Morikawa, vol. 54, pp. 19588-19589 (1960); and Seidlova, et al., vol. 62, pp. 11709-11710 (1965).

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