Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-03-17
1996-08-20
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514844, 514852, 514874, 514880, A61K 3158
Patent
active
055479570
ABSTRACT:
The instant invention involves a method of treating and/or reversing androgenic alopecia and promoting hair growth, and methods of treating acne vulgaris, seborrhea, and female hirsutism, by administering to a patient in need of such treatment a 5.alpha.-reductase 2 inhibitor, such as finasteride, in a dosage amount under 5 mgs/day.
REFERENCES:
patent: 4220775 (1980-09-01), Rasmusson et al.
patent: 4377584 (1983-03-01), Rasmusson et al.
patent: 4396615 (1983-08-01), Petrow et al.
patent: 4684635 (1987-08-01), Orentreich et al.
patent: 4760071 (1988-07-01), Rasmusson et al.
patent: 4859681 (1989-08-01), Rasmusson et al.
patent: 5049562 (1991-09-01), Rasmusson et al.
patent: 5053403 (1991-10-01), Orentreich et al.
patent: 5098908 (1992-03-01), Steinberg et al.
patent: 5120742 (1992-06-01), Rasmusson et al.
patent: 5151429 (1992-09-01), Rasmusson et al.
patent: 5162332 (1992-11-01), Steinberg et al.
patent: 5407944 (1995-04-01), Goldman
G. Gormley et al., "Effects of Finasteride (MK-906), a 5alpha-Reductase Inhibitor, on Circulating Androgens in Male Volunteers", J. Clin. Endo. Metab., vol 70, 1136-1141 (1990).
Transcript, WNBC-TV, News 4 NY Live at Five, Nov. 29, 1993.
A. Diani et al., "Hair Growth Effects of Oral Admin. of Finasteride, a Steroid 5alpha-Reductase Inhibitor . . . ", J. Clin. Endocrin. Metab., vol 74, 345-350 (1992).
J. Imperato-McGinley et al., "The 5-Alpha Reductase Inhibitor Finasteride Comparison of Male Pseudohermaphrodites . . . ", J. Clin. Endocrinol. Metab., vol. 70, 777-782 (1990).
Bingham, et al., "The Metabolism of Testosterone by Human Male Scalp Skin", J. Endocr., vol. 57, 111-121 (1973).
E. Stoner, et al., "Finasteride (MK-906) in the Treatment of Benign Prostatic Hyperplasia", Prostate, vol. 22, 291-299 (1993).
E. Stoner et al., "The Clinical Effects of a 5-Alpha-Reductase Inhibitor, Finasteride, on Benign Prostatic Hyperplasia", J. Urol., vol. 147, 1298-1302 (1992).
S. Sudduth et al., "Finasteride: The First 5-Alpha-Reductase Inhibitor", Pharmacotherapy, vol. 13, 309-325 (Jul.-Aug. 1993).
G. Gormley, et al., "The Effect of Finasteride in Men with Benign Prostatic Hyperplasia", New Engl. J. Med., vol. 327, 1185-1191 (1992).
H. Matzkin et al., "Prolonged Treatment with Finasteride (a 5-Alpha-Reductase Inhibitor) Dose Not Affect Bone Density and Metabolism", Clin. Endocrinol., vol 37, 432-436 (1992).
J. McConnell et al., "The Effects of Low-Dose Finasteride (MK-906) on Prostatic Androgen Levels in Men with Benign Prostatic . . . ", J. Urol., vol. 143, No. 4, Suppl., p. 267A (1990).
J. McConnell et al., "Finasteride, an Inhibitor of 5 Alpha-Reductase, Suppresses Prostatic Dihydrotestosterone in Men . . . ", J. Clin. Endocrin. Metab., vol. 74, 505-508 (Mar. 1992).
A. Vermeulen et al., Eur. Urol., vol. 20, Supp. 1, 82-86 (1991), "Hormonal Effects of a 5 Alpha Reductase Inhibitor (Finasteride) . . . ".
A. Vermeulen et al., "Hormonal Effects of an Orally Active 4-Azasteroid Inhibitor of 5-Alpha-Reductase in Humans", Prostate, vol. 14, 45-53 (1989).
B. Metcalf et al., "Inhibitors of Steroid 5-Alpha-Reductase in Benign Prostatic Hyperplasia, Male Pattern Baldness and Acne", Trends Pharmacol. Sci., vol. 10, 491-495 (1989).
C. Tempany, et al., "The Influence of Finasteride on the Volume of the Peripheral and Periurethral Zones of the Prostate . . . ", Prostate, vol. 22, 39-42 (1993).
Gormley Glenn J.
Kaufman Keith D.
Stoner Elizabeth
Waldstreicher Joanne
Fitch Catherine D.
Merck & Co. , Inc.
Quagliato Carol S.
Rose Shep K.
Winokur Melvin
LandOfFree
Method of treating androgenic alopecia with 5-.alpha. reductase does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of treating androgenic alopecia with 5-.alpha. reductase , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treating androgenic alopecia with 5-.alpha. reductase will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2330921