Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1981-06-24
1983-08-02
Roberts, Elbert L.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
2603973, A61K 3156
Patent
active
043966152
ABSTRACT:
A method of treating androgen-related disorders in an animal which comprises administering to the animal dihydrotestosterone level decreasing amounts of a compound of formula (I): ##STR1## wherein R is H or F; R.sup.1 is selected from the group consisting of --H; straight or branched chain lower alkyl; hydroxyl; --OCOR.sup.3 ; and O--(C.sub.1 -C.sub.6 alkyl); wherein R.sup.3 is --H, C.sub.1 -C.sub.10 straight or branched chain alkyl group, phenyl, phenyl alkylene having straight or branched chain C.sub.1 -C.sub.6 alkylene, C.sub.5 -C.sub.10 cycloalkyl or C.sub.6 -C.sub.10 cycloalkyl alkylene; R.sup.2 is H.sub.2, methylene, ethylidene, .alpha.-CH.sub.3 (H), .beta.-CH.sub.3 (H), .alpha.-(OH)(H) or the acetonide derived from the 16.alpha.,17.alpha.-dihydroxy derivative, and n is 1 or 2.
REFERENCES:
patent: 4055641 (1977-10-01), Benson et al.
Chemical Abstracts, vol. 67, (1967), Para. 91,029(p).
Lack Leon
Petrow Vladimir
Duke University
Roberts Elbert L.
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