Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-06-26
2000-12-05
Seaman, D. Margaret
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514340, 435810, 206570, A61K 3144, C12N 120, B65D 8124
Patent
active
061567655
ABSTRACT:
The present invention is drawn to a method of preventing or treating vasospasm by administering to a patient an effective amount of an iron chelator which preferentially chelates ferrous iron over ferric iron. The iron chelators to be use in the present invention are small compounds which can penetrate the blood-brain barrier and act intracellularly to chelate ferrous iron. The present invention further encompasses a kit to be used for the prevention and treatment of vasospasm with the method of the invention.
REFERENCES:
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Oubidar, M., et al, Free Radical Biology and Medicine, vol. 16(6), pp. 861-867, abstract only, Jun. 1994.
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Oubidar, M. et al, Free Radical Biology & Medicine, 1994, 16(6), pp. 861-867.
Comparative Study of Different Iron-Chelating Agents in Cold, Induced Brain Edema, Y. Ikeda et al., Neurosurgery, vol. 24, No. 6, 1989, pp. 820-824.
Cerebral Arterial Spasm. II Etiology and Treatment of Experimental Cerebral Vasospasm, H. Morooka, Acta Med. Okayama, vol. 32, No. 1, 1978, pp. 39-49.
Chemical Abstracts 124:106078, Vollrath, 1995.
Chemical Abstracts 118:57455, Harada, 1992.
Chemical Abstracts 113:95352, Simon, 19910, 1990.
Boock Robert J.
Horky Laura L.
Seaman D. Margaret
The United States of America as represented by the Department of
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