Drug – bio-affecting and body treating compositions – Lymphokine – Interleukin
Patent
1995-06-07
1998-03-03
Ulm, John
Drug, bio-affecting and body treating compositions
Lymphokine
Interleukin
514 2, 514 12, 514885, 530351, A61K 3819, C07K 1454
Patent
active
057231206
ABSTRACT:
This invention provides a class of interleukin-6 (IL-6) muteins which act as IL-6 receptor antagonists, thereby inhibiting the normal function of naturally-occurring IL-6. These IL-6 receptor antagonism are preferably IL-6 molecules containing one or more mutations in the Site II region comprising amino acids 154-163. This invention also provides pharmaceutical compositions comprising IL-6 receptor antagonists with a pharmaceutically acceptable carrier. This invention further provides methods for treating IL-6 related diseases such as sepsis and multiple myeloma, the methods comprising administering to a patient an IL-6 receptor antagonist.
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Aarden Lucien A.
Brakenhoff Just P. J.
Blackburn Robert P.
Central Laboratory of the Netherlands Red Cross Blood Transfusio
Chiron Corporation
Mertz Prema
Rin-Laures Li-Hsien
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